Propranolol 40 mg. 50 tablets

WHAT Propranolol Actavis AND WHAT IT IS USED
Propranolol Actavis is a non-selective beta-blocker. It has a stabilizing influence on the excitation of the heart muscle. The main effects of the product on the cardiovascular system is to improve the supply of oxygen to the heart and reducing the pain associated with angina, cardiac pacemakers, and a decrease in blood pressure. After myocardial infarction significantly reduces oxygen demand of the heart muscle, significantly reduced the incidence of reinfarction and mortality after myocardial infarction.
 
Propranolol Actavis is used in:
• High blood pressure of various origins (hypertension), alone or in combination with other antihypertensive agents;
• Angina pectoris (angina) due to atherosclerosis of the coronary arteries (the vessels that supply the heart with oxygen) - for prevention and long-term treatment;
• Rhythm cardiac disorders - supraventricular tachycardia (increased heart rate frequency) - paroxysmal atrial tachycardias by catecholamines and digitalis and syndrome of Wolf-Parkinson-White; prolonged uncontrolled be sinus tachycardia; tachycardias and Artymata in thyrotoxicosis; continuous atrial extrasystoles, atrial fibrillation and flutter failing to control ventricular rate with digitalis; ventricular arrhythmias (heart rhythm disturbances) - ventricular tachycardias; persistent ventricular extrasystoles; tachyarrhythmias in digitalis intoxication;
• Myocardial infarction - for long-term treatment after acute stage of myocardial infarction;
• Hypertrophic cardiomyopathy - alone or combination therapy;
• Thyrotoxicosis (overactive thyroid gland) - to complex therapy;
• Pheochromocytoma (a tumor of the adrenal gland) - for the treatment of accelerated heartbeat in combination with alpha-adrenergic blocking agents;
• Migraine - prevention of relapses;
• Essential tremor (shaking).
 
 
 
2. WHAT YOU NEED TO KNOW BEFORE TREATMENT 3APOCHNETE propranolol Actavis
 
Propranolol Actavis does not apply to:
• Hypersensitivity to the active and excipients;
• Severe cardiovascular disease;
• Cardiogenic shock;
• Hypotension;
• Sinus bradycardia below 50 bpm;
• AV block over P-III degree and SA-block;
• syndrome sick sinus;
• Raynaud's disease;
• Prinzmetal Angina;
• Bronchial asthma.
 
In this medicinal product, please note the following:
Propranolol Actavis treatment begins with small doses that are gradually increased according to individual patient sensitivity. Discontinuation of treatment should be to gradually reduce the dose for 8 to 10 days, especially in patients with angina pectoris, because abrupt withdrawal can cause an attack of heart pain (angina) or rhythm disorder.
When treated with Propranolol Actavis is necessary to monitor the pulse - at rest should not fall below 50-55 beats / min.
The product is used with caution in patients with impaired hepatic and renal funktsii.Kakto all other products in this group there is a risk of low blood pressure, which requires observation of the patient.
The product is used with caution in patients with bronchial asthma, SA-block syndrome sick sinus, Raynaud's disease and angina Prinzmetal.
Propranolol Actavis is not indicated for the treatment of hypertensive crisis. In elderly patients should be administered with caution, as can be observed increased or decreased sensitivity to his normal doses.
The product may change the symptoms decrease blood sugar (especially accelerated heartbeat), and to cause such even in patients who do not suffer from diabetes.
In need of surgery (including dental or emergency) physicians should be advised that the patient is on regular treatment with a beta-blocker.
In pheochromocytoma product should only be used after previous primary treatment with alpha-adrenergic blocker, because without accompanying alpha-blockade may lead to an excessive increase in blood pressure.
Be careful with increasing physical activity in oropharyngeal patients where the pain is decreased due to treatment.
In need of laboratory and functional studies to consider possible changes of some tests of beta-blockers - elevated levels of serum lipoproteins and triglycerides, increased serum potassium, false positive levels of catecholamines and their breakdown products in urine and blood, elevated of antinuclear antibodies negative screening tests for glaucoma.
In patients with a history, severe allergies to food, medicines or insect bites should be careful with the use of beta-blockers as they can worsen allergy. In any allergic reactions during treatment should be carried out medical konsultatsiya.Pri intake of antacids such as Almagel or koalgel, Propranolol Actavis be taken no earlier than two hours before or after their adoption.
Screening test for glaucoma may be compromised, since the use of beta-blockers resulted in a decrease in intraocular pressure.
 
 
Application of Propranolol Actavis with food and drink
No evidence of the need for special diets or restrictions on certain types of foods and beverages during treatment with this product.
 
 
Pregnancy
Before taking any medicine, consult your doctor or farmatsevtPropranolol Actavis not be used during pregnancy due to the fact that beta-blockers reduce blood flow to the placenta and can result in intrauterine fetal death or premature birth. There is an increased risk of cardiac and pulmonary complications in newborns.
 
 
Breastfeeding
Before taking any medicine, consult your doctor or farmatsevtPropranolol Actavis is excreted in human milk and not be used during breastfeeding.
 
 
Driving and using machines
The product is applied with caution to drivers of motor vehicles and machine operators due to the influence of reactions and induce vertigo and dizziness.
 
 
Information about excipients
The product contains lactose as an excipient. Is unsuitable for people with lactase deficiency, galactosemia or glucose / galactose syndrome malabsorbtsiya.Produktat contains wheat starch as an excipient, which can be dangerous for people with celiac disease (gluten enteropathy).
 
 
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines soon, even if they have not been prescribed by your doctor.
When concomitant administration of Propranolol Actavis with verapamil, diltiazem and MAOIs increases the cardio action. With concomitant use with insulin or sulfonylureas may mask the symptoms of a fall in blood sugar and increase the risk of occurrence and more difficult recovery from it.
Other antihypertensive drugs, vasodilators or psihofarmaka given concurrently with Propranolol Actavis amplify the decrease in blood pressure.
Centrally acting antihypertensive drugs such as reserpine, methyldopa, clonidine when used with Propranolol Actavis can further enhance its negative timer and dromotropic effects. Concomitant use with amiodarone appears complementary effect on conductivity, especially in patients with sinus node dysfunction or AV-node.
With concomitant use of anesthetics increases the risk of hypoglycemia, myocardial depression, slow heart rate and increased central venous pressure. When given in combination with haloperidol, cases of sudden cardiac death. Ethanol reduces absorption. Phenytoin and phenobarbital increase the secretion of the product. Co-administration of thyroxine leads to a low concentration of T3. Lidocaine reduces the release of Propranolol Actavis with concomitant use.
Cimetidine decreased hepatic elimination of Propranolol and resulted in an increase of plasma levels and therapeutic effect.
Antacids containing magnesium and aluminum salts, reduce the absorption mu.Nesteroidnite inflammatory drugs and in particular indomethacin reduces the effect of reducing the blood pressure of the product. Cocaine inhibits the therapeutic effect of Propranolol Actavis. Use of the product in cocaine abuse increases the risk otnastapvane hypotension, severe bradycardia (slow heart rate) and heart block due to the action of alpha-adrenergic blocking activity of cocaine.
With iodinated X-ray contrast agents may enhance the risk of moderate to severe anaphylactic (severe allergic) reaction, which is resistant to terapiya.Estrogenite reduce the antihypertensive effect of beta-blocker due to estrogen- induced fluid retention. Neuromuscular blocking agents can shine and prolong the effects of muscle relaxants to the extent of incomplete recovery of neuromuscular blockade.
Cessation of smoking may increase the therapeutic effects of Propranolol, since it reduces the metabolic rate of the product and increase plasma levels.
Concomitant use with phenothiazine derivatives causes incomplete increased plasma levels of both products.
Immunotherapy with allergens or use of allergens for skin tests, beta-blockers may increase the risk of serious allergic reactions to these medications.
With concomitant use of aminophylline, theophylline or caffeine may neutralize the therapeutic effects of both drugs than plasma levels of theophylline may increase.
 
 
3. HOW TO USE Propranolol Actavis
Always take Propranolol Actavis exactly as your doctor!
Administered orally with a moderate amount of liquid during or immediately after a meal.
• Hypertension - initial dose 20-40 mg (1 / 2-1 tablet) twice daily alone or in combination of a diuretic; usual maintenance dose is 120 mg to 240 mg daily;
• Angina pectoris - starting dose is 40 mg twice - three times a day; a therapeutic dose is from 80 mg to 320 mg daily, divided into 2 to 4 doses. The dosage is gradually increased by the physician to achieve a therapeutic effect or an optimum beta blockade;
• Rhythm disorders - 40 mg to 160 mg (1 to 4 tablets) daily, divided into four doses. The dose is gradually changed by the physician according to the therapeutic needs or to achieve optimum beta-blockade;
• Myocardial infarction - for continuous treatment following the acute phase of myocardial infarction - 20-40 mg (1 / 2-1 tablet) four times a day, the total daily dose may be increased to 240 mg, in divided doses, according to the therapeutic needs or to achieve optimum beta-blockade;
• Hypertrophic cardiomyopathy - 40 mg two to four times daily. The dose is gradually changed by a doctor according to the therapeutic needs or to achieve optimum beta-blockade;
• Pheochromocytoma - to combination therapy of 40-60 mg (G 1 1/2 tablets) per day (appointed to achieve lasting beta-blockade three days before surgery with alpha-adrenoblokirashta therapy). Propranolol Actavis should not be appointed before achieved at least partial beta-blockade!
In unresectable tumor, the daily dose is 20 mg -40 mg, divided into several doses.
• migraine - initial dose of 40 mg twice, three times a day; if needed, the dose may be increased gradually to 120 mg (based on individual tolerance indications or optimal beta-blockade).
In individual patients for the treatment of hypertension or angina pectoris is obtained good therapeutic effect with one or two occasions once daily regimen.
 
Elderly
The product is applied with caution, as the treatment starts with the lowest dose. The optimal dose is determined individually according to clinical response.
Children
The initial daily dose is 0.5 to 1 mg / Kg of body weight, divided into two to four times; maintenance dose - 2-4 mg / Kg, divided into two daily doses. Should not exceed 16 mg / kg daily doza.Ako have the impression that the effect of the application of Propranolol Actavis is too strong or too weak, talk to your doctor or pharmacist!
 
If you take a large amount of the drug:
When taking a higher dose than prescribed immediately consult a doctor! In case of overdose can occur any of the following symptoms -zabavena heartbeat, dizziness; drop in blood pressure, irregular heartbeat, bronchospasm; cold or blue fingers and toes.
Treatment
In an extreme drop in heart rate - atropine; in severe hypotension -dobutamin or dopamine; glucagon may be beneficial for bradycardia and hypotension in the treatment of beta-adrenergic blockade; according to the severity of symptoms may also be used a temporary pacemakers, furosemide, digitalis, beta-2 agonists (isoproterenol and / or aminophylline) in bronchoconstriction.
 
If you forget to use Propranolol Actavis
It is desirable not to pass a drug, especially if the product is assigned to a single dose. If this happens, the tablet should be taken immediately, but if it is near the next intake should not take the missed dose.
 
 
4. POSSIBLE SIDE EFFECTS
Like any other medicine Propranolol Actavis can cause side effects.
Adverse reactions are usually mild and transient, occurred early in treatment and continued until the patient adapts to it. Rarely require dose reduction or discontinuation. Can be observed side effects of various organs and systems:
• Cardiovascular system - worsening heart failure, slow heart rate, cardiac conduction disturbances, low blood pressure, abnormal blood flow in the limbs;
• Gastrointestinal system - dry mouth, upset stomach, nausea, diarrhea, constipation, colitis;
• Skin - aggravated psoriasis, mild allergic skin reactions;
• Musculoskeletal - transient muscle weakness; calf muscle cramps; cold extremities;
• Central nervous system - transient fatigue, headache, sweating, mild dizziness, sleep disturbances, depression and hallucinations, tingling in the arms, weakness, emotional lability;
• Eye analyzer - reduced tear production; conjunctivitis, visual disturbance;
• Metabolism - deterioration of glucose tolerance in diabetics; masking the symptoms of decline of blood sugar;
• Respiratory system - bronchial spasm;
• Genitourinary system Popova - a decrease in libido;
• Immune system - allergic skin reactions;
• Blood ~ reduced number of cells and suppression of white blood specific skin bleeding.
Some of these side effects for a longer duration require a reassessment of treatment and doses of doctor - reduced potency; dizziness; sleep problems; unusual tiredness during physical exertion; nervousness and tension.
If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
 
 
5. Storage
At temperatures below 25 ° C.
Keep out of reach of children!
Do not use after the expiry date stated on the package!
Shelf life: 3 (three) years