XYMERAL 1 mg. / Ml. 10 ml.

WHAT XYMERAL AND WHAT IT IS USED
The active substance of this medication is xylometazoline. It narrows blood vessels in the nasal mucosa, and thus reduces swelling due to various reasons, and facilitate breathing through the nose.
Ksimeral is used for short-term treatment of nasal congestion.

2. BEFORE YOU USE XYMERAL
Do not use XYMERAL
if you are allergic (hypersensitive) to xylometazoline or any of the other ingredients in the medicine;
if you have recently had brain surgery through the nose or mouth.
Take special care with XYMERAL
Ask your doctor or pharmacist before taking this medicine if you have:
tendency to hypersensitivity to sympathomimetic agents (drugs such as adrenaline); Ksimeral can cause insomnia, dizziness, tremors, arrhythmia, or an increase in blood pressure;
cardiovascular disease (heart disease, high blood pressure);
hyperthyroidism (overactive thyroid gland);
diabetes mellitus;
pheochromocytoma (a tumor in the medullary portion of the adrenal gland that produces hormones);
prostatic hypertrophy (enlarged prostate);
an inherited disease caused by defective enzymes (porphyria);
conducting a medication for depression (MAO inhibitors);
increased intraocular pressure (narrow-angle glaucoma);
chronic cold with scant or no secretion.
Mucosal edema (swelling of the lining of the nose) may occur at the termination of long-term treatment with xylometazoline. To prevent this, the period of treatment should be as short as possible.
If you think you have a bacterial infection, please consult your doctor as the infection should be treated promptly. This medicinal product must not be used by more than one person to prevent the risk of spreading infections.
If any of the above applies to you, consult your doctor before taking Ksimeral.

Using other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Not recommended for use of this drug with certain antidepressants, for example:
tri- or tetracyclic antidepressants;
MAOIs (monoamine oxidase inhibitors), or have taken MAOIs in the last two weeks.
Not also recommends the use of this medicine:
in combination with antihypertensive drugs (eg. methyldopa) due to potential hypertensive effects of xylometazoline;
with other drugs with a potential hypertensive effect (eg. doxapram, ergotamine, oxytocin), as they can potentiate their mutual hypertensive effects.
Pregnancy and lactation
Pregnant or lactating women should consult their doctor before taking this medicine.

Pregnancy:
Please consult your doctor before taking this medicine if you are pregnant. Use this medicine only if your doctor has determined that it is safe for you.

Lactation:
It is not known whether xylometazoline is excreted in breast milk. The risk to the infant can not be excluded. Must decide whether to discontinue nursing or to discontinue / do not use Ksimeral, taking into account the benefit of breast feeding for the child and the benefit of therapy for you.
As an overdose may lead to a decrease in milk production, the recommended dose of xylometazoline should not be exceeded during lactation.
Ask your doctor or pharmacist before taking any medicine.

Driving and using machines
When taken properly, this drug does not affect the ability to drive and use machines, but if you feel dopey or sleepy while using the drug should not drive or operate machinery.

3. HOW TO USE XYMERAL
Before the first administration is necessary to burst repeatedly (4 times) in the air to achieve a uniform dose. The bottle must be vertical. If the product is not used for several days, it should be done at least one test spraying in the air in order to achieve a uniform dose.
Ksimeral 1 mg / ml is reappointed to treat nasal congestion in children aged over 10 years and adults.

Dosage
The usual dose is 1-2 sprays in each nostril every 10-12 hours (not more than three times a day) for a maximum of 7 days.
Ksimeral 1 mg / ml is not recommended for children under the age of 10 years.
Patients aged under 10 years should use Ksimeral 0,5 mg / ml.

Duration of treatment
The duration of treatment should be as short as possible. After prolonged treatment is likely to reoccur swelling of mucosa (inner lining of the nose). Do not exceed the recommended dose. You should consult a doctor if you feel better, or if you feel worse after three days of continuous treatment.

If symptoms of the disease does not improve
Contact your doctor if symptoms of your illness persist or worsen after 7 days.
The doctor may give you different dosage instructions compared to the information provided in this leaflet with patient information. Always use Ksimeral exactly as described in this leaflet or as your doctor tells you. If you are not sure, ask your doctor or pharmacist.

Instructions for use
Blow your nose before using this medicine. Remove the cap.
Hold the bottle between your index and middle finger while keeping the bottom of the bottle with your thumb. Injection prime the pump down.
When you use this drug for the first time, spray several times (4 times) in the air to get a fine spray. It is also good to test the bulb by pressing down at least once.
Place the bulb into the nostril. Press the bulb down while inhale through your nose while gently squeezing the other nostril with the index finger of his free hand. Release the bulb and remove it from the nostril.
Repeat this procedure in the other nostril.
Wipe the bulb and place the plastic cap after use.

Note: if the same bottle is used by several people, this can cause spread of infection.

If you use more than the amount Ksimeral
If you (or someone else) you take an overdose of this medicine, see your doctor immediately. Overdosing can cause depression of the central nervous system, dry mouth, sweating and symptoms caused by stimulation of the sympathetic nervous system (rapid irregular heartbeat and blood pressure increase).

If you forget to use XYMERAL
If you forget to take a dose of this medicine, skip the missed dose and continue with the dosing regimen. Do not take a double dose to make up the missed dose.

If you stop using Ksimeral
If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS
Like all medicines, XYMERAL can cause side effects, although not everybody gets them.

Reported the following side effects:
Common side effects - likely to affect 1 to 10 users in 100 people:
itching or burning in the nose and throat;
dry nasal mucosa.
Uncommon side effects - likely to affect 1 to 10 users in 1,000 people:
systemic allergic reactions;
increased swelling of the nasal mucosa after treatment discontinuation;
epistaxis (nosebleeds).
Rare side effects - likely to affect 1 to 10 users in 10,000 people:
palpitations and rapid pulse;
nausea;
high blood pressure.
Very rare side effects - likely to affect less than 1 in 10,000 people:
nervousness;
insomnia;
fatigue;
headache;
arrhythmia;
mainly in children after overdose: drowsiness / somnolence, nervousness, insomnia, hallucinations and convulsions. Cases of irregular breathing are registered in infants and newborns.

5. HOW TO STORE XYMERAL
Keep out of the reach and sight of children.
XYMERAL not use after the expiry date stated on the carton after "EXP". The expiry date refers to the last day of that month. Be used within 3 months after opening.
Do not freeze. This medicine does not require any special storage conditions.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. FURTHER INFORMATION
What XYMERAL
The active substance is ksilometazolinov hydrochloride, one milliliter of solution contains 1 mg. 1 injection XYMERAL 1,0 mg / ml (= 90 microlitres) contains 90 micrograms ksilometazolinov hydrochloride.
The other ingredients are purified sea water, potassium dihydrogen phosphate and purified water.