TERTENSIF COMBI 2.5 mg. / 10 mg. 30 tablets

WHAT TERTENSIF COMBI 10 mg / 2,5 mg IS AND WHAT IT IS USED?
What is TERTENSIF COMBI 10 mg / 2,5 mg?
TERTENSIF COMBI 10 mg / 2,5 mg of a combination of two active ingredients perindopril and indapamide. It is an antihypertensive agent, and is used to treat high blood pressure (hypertension). TERTENSIF COMBI 10 mg / 2,5 mg is administered to patients already taking 10mg perindopril and indapamide 2,5 mg in separate tablets, these patients may instead receive one tablet TERTENSIF COMBI 10 mg / 2,5 mg, which contains both ingredients.
What is TERTENSIF COMBI 10 mg / 2,5 mg?
Perindopril belongs to a class of drugs called ACE inhibitors. They work by widening the blood vessels, which relieves the heart to pump blood through them. Indapamide is a diuretic. Diuretics increase the amount of urine produced by the kidney. However, indapamide is different from other diuretics, as it leads to a very slight increase in the amount of urine formed. Each of the active ingredients reduces blood pressure, and taken together they give rise to better control of blood pressure.
2. BEFORE YOU TAKE TERTENSIF COMBI 10 mg / 2,5 mg
Do not take TERTENSIF COMBI 10 mg / 2,5 mg
if you are allergic (hypersensitive) to perindopril or any other ACE inhibitor, or to indapamide or other sulfonamides or to any of the ingredients of TERTENSIF COMBI 10 mg / 2,5 mg,
if you have experienced symptoms such as wheezing, swelling of the face or tongue, intense itching or severe skin rashes with previous treatment with an ACE inhibitor or if your blood relatives have had in other circumstances such symptoms (a condition called angioedema)
if you have severe liver disease or suffer from a condition called hepatic encephalopathy (degenerative brain disease)
if you have kidney disease or are on dialysis,
if you have low or high blood potassium,
if there is doubt that you are untreated cardiac decompensation (severe water retention, difficulty in breathing)
if you are pregnant after the third month (better also avoid TERTENSIF COMBI 10 mg / 2,5 mg in early pregnancy - see "Pregnancy and lactation")
if you are breastfeeding.
Take special care with TERTENSIF COMBI 10 mg / 2,5 mg
If any of these characteristics apply to you, tell your doctor before taking TERTENSIF COMBI 10 mg / 2,5 mg:
if you have aortic stenosis (narrowing of the main blood vessel leaving the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood),
if you have other heart problems
if you have liver problems
if you have a collagen disease (skin disease) such as systemic lupus erythematosus or scleroderma,
if you have atherosclerosis (hardening of the arteries)
if you suffer from hyperparathyroidism (overactive parathyroid gland), if you suffer from gout, if you are diabetic
if you are on a diet with restriction of salt and use salt substitutes containing potassium,
if you take lithium or potassium-sparing diuretics (spironolactone, triamterene) as their use with TERTENSIF COMBI 10 mg / 2,5 mg should be avoided (see "Taking other medicines").
Tell your doctor if you think you are pregnant or might become pregnant. TERTENSIF COMBI 10 mg / 2,5 mg is not recommended in early pregnancy and must not be taken if you are pregnant after the third month, as it may seriously harm your baby if used during this period (see. "Pregnancy and breastfeeding ").
If you take TERTENSIF COMBI 10 mg / 2,5 mg, you should tell your doctor or medical staff:
if you need to be subject to (a) of anesthesia and / or surgery
If you have recently had diarrhea or vomiting, or are dehydrated (a)
if you need to be subject to (a) on dialysis or LDL apheresis (which represents the removal of cholesterol from your blood by a machine)
if you need to be subject to (a) of desensitization to reduce the effects of an allergy to bee stings or wasp
if you need to be subject to (a) a medical examination, which requires the injection of iodine-containing contrast agent (a substance that makes it visible on X-ray organs like kidney or stomach).
Athletes should be aware that TERTENSIF COMBI 10 mg / 2,5 mg contains an active ingredient (indapamide) which may cause a positive results in doping control.
TERTENSIF COMBI 10 mg / 2,5 mg should not be given to children.
Taking other medicines
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. It should avoid the use of TERTENSIF COMBI 10 mg / 2,5 mg to:
- Lithium (used to treat depression)
- Potassium-sparing diuretics (spironolactone, triamterene), potassium salts, treatment TERTENSIF COMBI 10 mg / 2,5 mg may be affected by other medicines. Be sure to tell your doctor if you are taking any of these medicines as you may need special attention:
- Other drugs for the treatment of high blood pressure,
- Procainamide (to treat irregular heartbeat)
- Allopurinol (for the treatment of gout),
- Terfenadine and astemizole (antihistamines for hay fever or allergies)
- Corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis,
- Immunosuppressants used to treat autoimmune disorders or following transplant surgery to prevent rejection of the transplanted organ (eg. Cyclosporin)
- Drugs to treat cancer,
- Injection erythromycin (antibiotic),
- Halofantrine (used to treat certain types of malaria)
- Pentamidine (used to treat pneumonia)
- Vincamine (used to treat symptomatic cognitive disorders in elderly including memory loss)
- Bepridil (used to treat angina)
- Sultopride (to treat psychoses)
- Medicines used for heart rhythm problems (eg. Quinidine, hydroquinidine, disopyramide, amiodarone, sotalol)
- Digoxin or other cardiac glycosides (for the treatment of cardiac problems),
- Baclofen (to treat muscle stiffness occurring in diseases such as multiple sclerosis)
- Drugs to treat diabetes such as insulin or metformin,
- Calcium supplements including calcium supplements
- Laxatives stimulate peristalsis (eg. Senna)
- Nonsteroidal antiinflammatory drugs (eg., Ibuprofen), or high doses of salicylates (eg. Aspirin),
- Amphotericin B injection (to treat acute fungal diseases),
- Drugs to treat psychiatric disorders such as depression, anxiety, schizophrenia ... (eg. Tricyclic antidepressants, neuroleptics),
- Tetracosactide (for the treatment of Crohn's disease).
Taking TERTENSIF COMBI 10 mg / 2,5 mg with food and drink
Preferably TERTENSIF COMBI 10 mg / 2,5 mg to be taken before meals.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
pregnancy
Tell your doctor if you think you are pregnant or might become pregnant. Your doctor will normally advise you to stop taking TERTENSIF COMBI 10 mg / 2,5 mg, before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead TERTENSIF COMBI 10 mg / 2,5 mg. TERTENSIF COMBI 10 mg / 2,5 mg is not recommended in early pregnancy, and should not be taken after the third month of pregnancy because it may cause serious harm to your baby if used after the third month of pregnancy.
breastfeeding
Tell your doctor if you are breastfeeding or if you intend to start breast-feeding. TERTENSIF COMBI 10 mg / 2,5 mg is contraindicated in mothers who are breastfeeding, and your doctor may choose another treatment for you if you want to breastfeed, especially if your baby is newborn or preterm.
Talk to your doctor immediately.
Driving and using machines
TERTENSIF COMBI 10 mg / 2,5 mg usually does not affect the state of alertness, but some patients may occur individual reactions such as dizziness and weakness associated with lower blood pressure. As a result, this can impair the ability to drive or operate machinery.
Important information about some of the ingredients of TERTENSIF COMBI 10 mg / 2,5 mg
TERTENSIF COMBI 10 mg / 2,5 mg contains lactose (a type of sugar). If your doctor has told you that you have an intolerance to some sugars, contact him before taking this medicine.
3. HOW TO TAKE TERTENSIF COMBI 10 mg / 2,5 mg?
Always take TERTENSIF COMBI 10 mg / 2,5 mg exactly as your doctor has told you. If you're not sure, ask your doctor or pharmacist. The usual dose is one tablet daily. It is preferable to take the tablet in the morning and before meals. Take the tablet with a glass of water.
If you take more than the amount TERTENSIF COMBI 10 mg / 2,5 mg
If you take more tablets immediately contact your doctor or the nearest medical facility for emergency assistance. If your blood pressure drops significantly (symptoms are dizziness or fainting), filling a horizontal posture with legs raised, you may be beneficial.
If you forget to take TERTENSIF COMBI 10 mg / 2,5 mg
It is important to take your medicine every day as regular treatment is more effective. However, if you forget to take a dose TERTENSIF COMBI 10 mg / 2,5 mg, take the next dose at the usual time. Do not take a double dose to make up for a missed tablet.
If you stop taking TERTENSIF COMBI 10 mg / 2,5 mg
As the treatment of blood pressure is usually for life, you should consult with your doctor before you stop taking this medicine.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, TERTENSIF COMBI 10 mg / 2,5 mg can cause side effects, although not everybody gets them.
If you experience any of these effects, stop taking the medicinal product immediately and tell your doctor immediately:
swelling of the face, lips, mouth, tongue or throat, difficulty in breathing, severe dizziness or fainting, unusually fast or irregular heartbeat.
In descending order of frequency side effects could be the following:
Common (occurs in less than 1 in 10 users but in more than 1 in 100 users): headache, dizziness, vertigo, tingling, visual disturbances, tinnitus (sensation of tinnitus) dizziness due to low blood pressure, cough, shortness of breath, gastrointestinal disorders / nausea, vomiting, abdominal pain, altered taste, dry mouth, indigestion, diarrhea, constipation), allergic reactions (eg. skin rashes , itching, muscle cramps, feeling tired,
Uncommon (occurs in less than 1 in 100 users but more than 1 in 1,000 users): mood swings, sleep disturbances, bronchospasm (chest tightness, wheezing and shortness of breath), angioedema (symptoms eg. wheezing, swelling of the face or tongue), urticaria (hives), purpura (red punctuate rash), kidney problems, impotence, sweating,
Very rare (affects less than I of 10,000 users): confusion, cardiovascular disorders (irregular heart beat, angina (angina), heart attack), eosinophilic pneumonia (a rare type of pneumonia), rhinitis (stuffy or runny nose ), severe skin manifestations such as erythema multiforme. If you suffer from systemic lupus erythematosus (a type of collagen) may deteriorate. There have been reports of outbreaks of photosensitivity (changes in skin appearance) after exposure to sunlight or artificial UV rays.
Not known (from the available data can not be estimated frequency): fainting, life-threatening heart rhythm disorders (Torsades de pointes), changes in the electrocardiogram, elevated liver enzymes.
Possible blood disorders, kidney, liver or pancreas (pancreas) and changes in laboratory parameters (blood tests). You may need your doctor to blood tests to monitor your condition.
In cases of hepatic insufficiency (liver problems), there is a risk of the occurrence of hepatic encephalopathy (degenerative brain disease).
If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.
5. HOW TO STORE TERTENSIF COMBI 10 mg / 2,5 mg?
Keep out of reach of children.
Do not use TERTENSIF COMBI 10 mg / 2,5 mg after the expiry date stated on the carton and container. The expiry date refers to the last day of that month.
Keep container tightly closed to protect from moisture.
Medicines should not be disposed of in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
6. FURTHER INFORMATION
What TERTENSIF COMBI 10 mg / 2,5 mg?
The active substances are perindopril arginine and indapamide. One tablet contains 1 Omg perindopril arginine (corresponding to 6,79 mg perindopril) and 2,5 mg indapamide. The other ingredients in the tablet core are lactose monohydrate, magnesium stearate (E470V), maltodextrin, silica, hydrophobic colloidal (E551), sodium starch glycolate (type A) and in the film coating of the tablet: glycerol (E422), hypromellose ( E464), macrogol 6000, magnesium stearate (E470V), titanium dioxide (E17I).
Looks TERTENSIF COMBI 10 mg / 2,5 mg and contents of the pack?
TERTENSIF COMBI 10 mg / 2,5 mg, film-coated tablets are white, round tablets. One tablet contains 10 mg of arginine and perindrpril 2,5 mg indapamide. The tablets are sold in containers of 14,20,28,30, 50, 56,60,90,100 or 500 tablets. Not all pack sizes may be marketed.