PHYSIOTENS 0.2 mg. 28 tablets

What is Physiotens and what is it used?
Each tablet contains 0.2 or 0.4 mg moxonidine. Fiziotens is used to treat hypertension.
 
How does Physiotens?
Physiotens selective imidazoline receptor agonist (Syrah). In various animal models has Physiotensshown that a strong antihypertensive action. Available experimental data indicate that the site of the antihypertensive action of Fiziotens is CNS (central nervous system). It has been shown that Fiziotens activated selectively called. imidazoline receptors in the brainstem. These receptors are extremely important for the central control of the peripheral sympathetic nervous system activation thereof results in the reduction of sympathetic activity and to lower blood pressure.
Fiziotens differs in that it exhibits only a weak affinity for known alpha-2-adrenoceptors relative to its effects on the imidazoline receptors. This affinity explains the lower incidence of depression of the nervous system (calm), or dry mouth when administering Fiziotens.
In humans Fiziotens leads to a reduction in systemic vascular resistance and thus to a reduction in blood pressure. Antihypertensive effect of Fiziotens is proven in double-blind, placebo-controlled, randomized clinical trials. .In Bimonthly therapeutic study has found Mr improve insulin sensitivity by 21% in the application of Fiziotens compared to placebo in patients with obesity and insulin resistant degree with an average grade hypertension.
 
2. Before you start taking Physiotens
Do not take Physiotens if:
- You are allergic to any component of the product
- Suffer from the syndrome sick sinus bradycardia or (your pulse at rest is below 50 beats per minute).
Take special care when taking Fiziotens:
If Fiziotens used together with beta-blocker and if the two drugs should be discontinued, the beta-blocker should be discontinued first and only then to be stopped Fiziotens.
When taken with other medicines:
Please tell your doctor or pharmacist if you are taking or have recently taken any medicines, including medicines obtained without a prescription.
Administered with other drugs for high blood pressure:
Physiotens safe use of thiazide diuretics and calcium channel blockers. Concomitant use with these and other antihypertensive drugs leads to an additive (additive effect, overlay effects) efekt.Pri healthy volunteers, no pharmacokinetic interaction was observed in the application of Fiziotens with hydraulic ohlortiazid, glibenclamide (glyburide) or digoksin.Tay as tricyclic antidepressants may reduce the effects of centrally acting antihypertensive drugs is not recommended tricyclic antidepressants can be co-administered with Fiziotens. There were no interactions with any farmokodinamichni moklobemid.Fiziotens leads to some improvement in impaired kongnitivna (cognitive) function in patients receiving lorazepam. Fiziotens may enhance the sedative (calming) effect of benzodiazepines in co-administration.
Pregnancy
No clinical studies Physiotens child. Animal studies do not indicate direct or indirect harmful effects on pregnancy, embryo / fetal development, birth and after birth period. Caution should be used when prescribing to pregnant women.
 
Breastfeeding
Physiotens is excreted in human milk. Women lactating should be advised not to breastfeed when treated with Fiziotens or stop taking the drug.
 
Driving and using machines
There is no evidence to suggest that Physiotens adversely affects driving or operating machinery. Drowsiness and dizziness. This should be taken into account in the implementation of these activities.
 
Important information about some of the ingredients of Physiotens
Lactose monohydrate: If your doctor has said that you have an intolerance to some sugars, contact him before taking this medicine.
 
3. How to take Physiotens ?
The usual starting dose is 0.2 mg Physiotens day with a maximum daily dose of 0.6 mg, given as two divided doses. The maximum single dose that can be administered is 0.4 mg. The daily dose is determined according to individual response to patsienta.Physiotens can be taken with or without hrana.Pri patients with moderate to severe renal impairment, the starting dose is 0.2 mg daily. If necessary and well tolerated, the dose may be increased to 0.4 mg dnevno.Pri hemodialysis patients the initial dose is 0.2 mg daily. If necessary and well tolerated, the dose may be increased to 0.4 mg dnevno.Ne defined safety and effectiveness of Fiziotens in patients under 18 years.
If you take a large amount Physiotens than you should:
Symptoms of overdose
There have been some cases of overdose in absorbed dose to 16 mg with no fatalities. Reported signs and symptoms include: headache, sedapiya, drowsiness, low blood pressure, dizziness, malaise, bradycardia (slow heart rate), dry mouth, vomiting, fatigue and stomach pains.
In cases of overdose, according to data from several toxicological tests on animals can be obtained hypertension (high blood pressure), tachycardia (increased heart rate) and hyperglycemia (high blood sugar).
 
Management of overdose
There is no known specific antidote. In cases of hypotension (low blood pressure) is recommended circulating maintenance such as fluid intake and administration of dopamine. Bradycardia can be treated with atropine, alpha-receptor antagonist could reduce or eliminate the paradoxical hypertensive effect of overdose Fiziotens.
If you forgot to take your dose Physiotens
Do not take a double dose to make up for a missed dose.
 
Effects when discontinuing treatment with Physiotens
Fiziotens treatment should not be stopped suddenly.
 
4. Possible side effects of Physiotens
Like all medicines, Fiziotens can have side effects. If you notice any side effects not listed in this leaflet, please ask your doctor or pharmacist.
Common (incidence 1 -10%), headache, dizziness, drowsiness, dry mouth, weakness. Uncommon (incidence <1%), sleep disturbances, nausea, skin rashes, itching Rare (frequency <0.1%), hypotension, orthostatic hypotension (drop in blood pressure upon standing)
Very rare (incidence <0.01%) angioedema
 
5. Storing Physiotens
Physiotens 0.2 mg: Do not store above 25 ° C.
 
Keep the medicine in the original container.
Do not use after the expiry date stated on the packaging. Keep this medicine out of the reach of children.
 
SHELF LIFE
Physiotens 0.2 mg: 2 years