PANCEF 100 mg. / 5 ml. 60 ml.

PANCEF WHAT IS AND WHAT IT IS USED
Pancef (cefixime) is an oral cephalosporin aminothiazole group. Cefixime showed activity, both in vitro and in clinical infections against most strains of the following organisms: Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae and the like.

Pancef recommended for the treatment of infections caused by cefixime-sensitive microorganisms, namely:
acute infections of the upper and lower respiratory tract, including. pharyngitis and tonsillitis, acute bronchitis and acute exacerbations of chronic bronchitis, pneumonia, acute and exacerbated chronic sinusitis;
Acute otitis media (acute otitis media);
urinary tract infections;
uncomplicated gonorrhea (cervical / urethral).

2 BEFORE YOU TAKE PANCEF
Do not take Pancef if:
you are allergic (hypersensitive) to cefixime, other cephalosporin antibiotics, or any of the excipients of Pancef.
Take special care with Pancef if:
you have or have ever had an allergic reaction to penicillin, other drugs or in case of other allergic manifestations (allergic reaction may include rash, itching, swelling, unusual joint pain, or difficulty breathing). If an allergic reaction occurs, the drug should be discontinued;
have kidney problems or diseases of the gastrointestinal tract (especially colitis).
Continuous treatment with cefixime may lead to superinfection with non-susceptible organisms.
If severe watery diarrhea, accompanied by fatigue and fever (pseudomembranous colitis), stop using Pancef and tell your doctor. No data on the efficacy and safety of cefixime in children under 6 months of age.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
It is essential if you are taking any of the following medicines:
Probenecid slows elimination of cefixime and increased plasma concentration;
Carbamazepine - cefixime increases the concentration of carbamazepine in concomitant;
aminoglycosides - aminoglycosides increase the risk of kidney damage;
anticoagulants - cefixime may prolong prothrombin time.
Taking cefixime can lead to false positive some laboratory tests.
While taking the drug should not be done protivotifna vaccination.

Taking Pancef with food and drink
Pancef can be taken without regard to food.

Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
The medicinal product is not recommended for pregnant women, especially during the first three months and the last six weeks, and in nursing mothers should proceed with caution.
This medicinal product is intended for pediatric use.

Driving and using machines
Cefixime not affect your ability to drive or operate machinery. This medicinal product is intended for pediatric use.

Important information about some of the ingredients of Pancef
Pancef granules for oral suspension containing 2,517 g of sucrose per 5 ml prepared suspension. This should be considered in patients with diabetes mellitus (diabetes mellitus).

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product. This product can damage teeth.

3 HOW TO TAKE PANCEF
Always take Pancef exactly as your doctor tells you. If you are not sure, ask your doctor or pharmacist.

Children up to '12 age or weighing less than 50 kg: 8 mg / kg daily taken as a single daily oral dose or divided into two equal oral dose of 4 mg / kg every 12 hours.
Weight (kg) Dose / day (ml)
to 6.0
2.5
6.0 - 12.5 2.5-5.0
12.5 - 25.0
5.0-10.0
25.0 - 37.5 10.0-15.0
Over 37.5 15.0-20.0
No data on the efficacy and safety of cefixime in children under 6 months of age.

Children over the '12 age (or weight over 50 kg) receive adult dosage. The usual adult dose is 400 mg daily taken as a single daily oral dose or divided into two equal oral dose of 200 mg every 12 hours. The inflammation of the middle ear to be treated with a suspension and the replacement of tablets is not recommended.
Usually a course of treatment is 7 days. Treatment may be continued for up to 14 days according to the severity of the infection.
Streptococcal infections are to be treated at least 10 days.

Patients with severe renal insufficiency should not take half the standard dose daily.

Reconstitution
Pancef suspension should be prepared immediately before use:
60 ml suspension: The bottle is shaken vigorously. Add 40 ml of water, divided into two parts and should be well shaken.
100 ml suspension: The bottle is shaken vigorously. Add 66 ml of water, divided into two parts and should be well shaken. Before use, shake the bottle well!

If you take more than you should Pancef
If you take more than you should, immediately contact your doctor or pharmacist.
In case of overdose, gastric lavage is recommended. There is no specific antidote.
Cefixime can be removed by hemodialysis or peritoneal dialysis.

If you forget to take Pancef
In case of failure of the intake, the next dose should be taken as soon as possible. If it is almost time for your next dose, the missed dose should be skipped and the treatment should continue the established pattern. Do not take a double dose to make up for a missed dose.

If you stop taking Pancef
Do not stop taking medication without consulting your doctor. Do not stop taking Pancef, just because you feel better as the infection may reoccur.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4 POSSIBLE SIDE EFFECTS
As with all medications, Pancef can cause side effects, although not everyone gets them.
If any of these symptoms occur, it is important to tell your doctor because if you do not pay attention may occur more serious complications.
Adverse reactions are listed according to their frequency:
Uncommon (affecting less than 1 in 100 patients but more than 1 in 1000 patients): diarrhea, abdominal pain, indigestion, flatulence (bloating), nausea and vomiting, headache, or dizziness.

Rare (affecting less than 1 in 1000 patients but more than 1 in 10,000 patients): hypersensitivity reactions (skin rashes, urticaria, drug fever and itching), transient elevations in ALT, AST and alkaline phosphatase, genital itching, vaginitis, candidiasis.

Very rare (affecting less than 1 in 10 000 patients but more than 1 in 100 000 patients): transient thrombocytopenia, leukopenia and eosinophilia (abnormalities in the number of certain types of blood cells), prolonged prothrombin time, heavy skin reactions such as erythema multiforme syndrome Steven Johnson; reactions resembling serum sickness, pseudomembranous colitis, transient elevations in blood urea nitrogen and creatinine.

If any of the side effects gets serious, or if you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

5 HOW TO STORE PANCEF
Keep out of reach of children.
Do not use Pancef granules for oral suspension after the expiry date stated on the package (for expiry date abbreviation used). The expiry date refers to the last day of that month.
Reconstituted suspension is stable 14 days stored at temperatures below 25 C. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6 FURTHER INFORMATION
Contents Pancef
The active substance is cefixime. 5 ml (1 measuring spoon) oral suspension contains 100 mg of cefixime trihydrate form.
The other ingredients are sucrose, xanthan gum, sodium benzoate, flavor of orange.

Pancef looks like and contents of the pack
Pancef granules for oral suspension are white to cream-colored granular powder with a pleasant orange flavor.
Glass bottle of 150 ml, containing 60 ml oral suspension and measuring spoon, a carton.
Glass bottle of 150 ml, containing 100 ml oral suspension and measuring spoon, a carton.