MOXOTENS 0.2 mg. 30 tablets

WHAT MOXOTENS AND WHAT IT IS USED
Moxotens is a medicinal product by a group called antihypertensive drugs with central action. The therapeutic effect is the reduction of high blood pressure. This is achieved by reducing the pressure in the peripheral vessels, obtained by the action of the sympathetic nervous system (reduction in peripheral vascular resistance), while at the same time the cardiac output and heart rate did not change significantly.
Moxotens be used for the treatment of arterial hypertension (high blood pressure).

2. WHAT YOU NEED TO KNOW BEFORE Moxotens

Moxotens not apply to:
• Allergy to the active substance or to any of the excipients;
• Atrial disturbances in heart rhythm and conduction (syndrome sick sinus or sinuatrialen block);
• Cardiac conduction (AV-block II-nd and III-rd degree);
• Expressed decrease in heart rate (heart rate <50 beats / minute);
• Severe heart failure;
• Expressed coronary insufficiency or unstable angina;
• Severe renal impairment ((creatinine clearance <30 ml / mm),
• Severe hepatic impairment;
• Pregnancy and lactation;
• Children.

In the application of this product, please note the following:
Should not be used due to lack of sufficient therapeutic experience, the following diseases and conditions:
• Raynaud's disease;
• intermittent claudication;
• Parkinson's disease;
• Epilepsy;
• Glaucoma;
• Depression.
If moxonidine is used in combination with beta-blocker and treatment should be discontinued, you first need to stop taking a beta blocker and a few days to stop the application of moksonidin.Pri patients with moderate renal impairment (creatinine clearance between 30 ml / min and 60 ml / min and serum creatinine> 105 mmol / 1 / but <160 mmol / l), the blood pressure lowering effect of moxonidine should be monitored closely, especially at the beginning of lechenieto.Poradi insufficient clinical data supporting the safety of use in patients with moderate heart failure, moxonidine should be used with caution in tyah.Poradi lack of therapeutic experience, the use of moxonidine in combination with tricyclic antidepressants or alcohol should be izbyagva.Lechenieto with moxonidine should not be stopped abruptly, and should be done gradually over a period of two weeks.

Application of Moxotens and intake of foods and drinks:
No evidence of the need for special diets or restrictions on certain types of foods and beverages during treatment with this product.

pregnancy
Before taking any medicine, consult your doctor or farmatsevt.Poradi lack of safety data, moxonidine is contraindicated during pregnancy.

breastfeeding
Before taking any medicine, consult your doctor or farmatsevt.Moksonidin is excreted in human milk. Therefore, it is not recommended its use during lactation. If the application is urgent need to stop breastfeeding.

Driving and using machines
There is no evidence to suggest that moxonidine adversely affects driving or operating machinery. However, in some cases detected fatigue and dizziness. This should be taken into account in the implementation of these activities.

Important information about some of the ingredients of Moxotens
This medicinal product contains lactose as an excipient, which makes it unsuitable for patients with lactase intolerance.


Taking other medicines:
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, even if they have not been prescribed by your lekar.Ednovremennoto adopting other hypotensive (blood pressure lowering) drugs enhances the hypotensive effect of moxonidine.
Coadministration Moxonidine with beta blockers may enhance their effect in slowing heart rate. The effect of alcohol, sedatives (tranquilizers) and hypnotics (sleeping pills) may be increased when co-administered with moxonidine. Concomitant use of benzodiazepines can increase the sedative them efekt.Mozhe appear additional sedative (calming) effect of concomitantly administered monoamine oxidase inhibitors.


3. HOW TO TAKE Moxotens
Always Moxotens as instructed by your doctor. On prescription! It is orally with sufficient fluid without regard to hrana.Lechenieto should start with the lowest dose Moxotens. This means a daily dose of 0.2 mg moxonidine, once in the morning. If the therapeutic effect is not satisfactory, after three weeks, the dose can be increased to 0.4 mg. This daily dose can be taken all at once or be divided into two daily doses. If the responder is still unsatisfactory, after further three weeks the daily dose may be increased to a maximum of 0.6 mg per day, given in two divided daily doses. A daily dose of 0.6 mg and a single dose of 0.4 mg should not be exceeded.
For patients with moderate renal impairment (creatinine clearance between 30 ml / min and 60 ml / min) the maximum single dose should not exceed 0.2 mg, the maximum daily dose of 0.4 mg.

children:
This product is not recommended for children and adolescents under 18 years. Their safety and efficacy have not been established.
If you have the impression that the effect of the application of Moxotens is strong or too weak, talk to your doctor or pharmacist.

If you have used more than the prescribed dose Moxotens
When taking a higher dose than prescribed, immediately contact a doctor! In most cases the dose to 2.0 mg daily was tolerated without the appearance of serious side reaktsii.Pri adults can expect these symptoms of overdose with moxonidine: sedation, low blood pressure, orthostatic dysregulation (a sudden drop in blood pressure when standing up), dry mouth. In rare cases, nausea and paradoxical increase in blood pressure.
Recommended measures to maintain cardiovascular tsirkulatsiya.Ne specific antidote is known. Phentolamine (Rezhitin) can counteract some of the symptoms.
If symptoms of overdose, immediately contact a doctor! If you forget to use Moksotens
If you miss a dose, take it at the next regular intake without increasing the dose.


4. POSSIBLE SIDE EFFECTS
Like all medicines, Moxotens can cause adverse reaktsii.V early treatment is often observed dry mouth and headache, less fatigue, weakness, dizziness, nausea and sleep disorders. Sedative (sedative) effect is set to less than 1% of patients.
The frequency and duration of these symptoms often decreases during the treatment.
In very rare cases registered allergic skin reactions. Isolated cases of angioedema (allergic reaction with swelling of soft tissue mainly on the face and throat) .If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist .


5. Storage
Keep out of reach of children.
At temperatures below 30 ° C.
Do not use after the expiry date stated on the package! Shelf life: two (2) years from date of manufacture.