XEFO RAPID 8 mg. 10 tablets

WHAT XEFO RAPID AND WHAT IT IS USED?
Xefo Rapid is a nonsteroidal anti-inflammatory and antirheumatic means Class oxicams. Intended for short term relief of mild to moderate pain.

BEFORE YOU TAKE XEFO RAPID
Do not take Xefo Rapid:
- If you are allergic to Ksefo or any of the other components of Rapid Ksefo
- If you suffer from thrombocytopenia
- If you are hypersensitive to other NSAIDs including acetylsalicylic acid
- If you suffer from gastrointestinal bleeding, cerebrovascular bleeding or other bleeding disorders
- If you have a history of gastrointestinal bleeding or perforation, related to previous treatment with NSAIDs
- If you suffer from an active or have a history of recurrent peptic ulcer
- If you suffer from severe liver damage
- If you suffer from severe renal impairment
- If you are pregnant in the last three months of pregnancy

Taking other medicines
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription
Xefo Rapid may interfere with other drugs.
Particular attention should be paid if you are taking any of the following substances:

- Cimetidine
- Anticoagulants such as heparin, phenprocoumon,
- methotrexate
- Lithium
- Immunosuppressive agents such as cyclosporin, tacrolimus
- Cardiac drugs such as digoxin, ACE inhibitors, beta-adrenergic blockers
- Diuretics
- Beta-blockers
- Quinolone antibiotics
- Antiplatelet agents
- NSAIDs such as ibuprofen, acetylsalicylic acid
- Inhibitors of Serotonin Reuptake
- Sulphonylureas
- Inducers and inhibitors of CYP2C9-isoenzymes
- Angiotensin II-receptor blockers
- pemetrexed

ADMISSION OF XEFO RAPID FOOD AND BEVERAGES
Rapid Xefo are intended for oral administration and should be taken before meals with a sufficient amount of liquid.

Co-administration with food may reduce the absorption of the drug.

Pregnancy and lactation:
Ask your doctor before taking any medicine. Xefo Rapid should not be taken during the first six months of pregnancy and breastfeeding women. You should not take Ksefo in the last three months of pregnancy.

When using Xefo Rapid may impair fertility, as its use in women attempting to become pregnant is not recommended. You should consider discontinuation of Ksefo in women who have difficulty conceiving or who are undergoing investigation of infertility.

HOW TO TAKE XEFO RAPID?

Adults: the usual dose is 8-16 mg divided in doses of 8 mg twice daily. On the first day of treatment may be given an initial dose of 16 mg, followed by 8 mg 12 hours later. After the first day of treatment, the recommended maximum daily dose is 16 mg.
Xefo Rapid tablets must be swallowed with sufficient fluid. Do not take Ksefo Rapid during meals because food may reduce the efficacy of Ksefo Rapid.
In the absence of data Xefo Rapid is not recommended for use in children and adolescents under 18 years.

POSSIBLE SIDE EFFECTS
- Difficulty breathing, chest pain, swelling or deterioration of their
- Severe or persistent stomach pain or if your stools acquire black
- Yellowing of the skin and eyes - these are signs of liver problems
- Allergic reactions - which can include skin problems such as ulcers or blisters, or swelling of the face, lips, tongue or throat that may cause difficulty in breathing.
- Fever, rash with blisters or sores, especially the hands and feet or around the mouth
- Exceptionally, severe skin infection in chicken pox

The known side effects include:
Common - mild and transient headache, dizziness, nausea, abdominal pain, dyspepsia, diarrhea, vomiting
Uncommon - anorexia, insomnia, depression, conjunctivitis, vertigo, tinnitus, heart rate, flushing, constipation, flatulence, belching, dry mouth, gastritis, gastric ulcer, pain in the upper abdomen, mouth ulceration, increase the values of liver function tests, rash, pruritus, increased sweating, urticaria, hair loss, joint pain, facial edema, weight changes, edema, allergic.

Rare - sore throat, anemia, low platelet count and white blood cells in the blood, hypersensitivity, anaphylactic reaction, confusion, nervousness, agitation, somnolence, dysgeusia, tremor, migraine, hypertension, flushing, shortness of breath, cough, blood faeces, bone pain, eczema, muscle cramps, muscle aches, night urination, abnormal urination, fatigue, prolonged bleeding, skin rash, increased blood urea

Very rare - liver damage, hepatitis, jaundice, biliary stasis in the bile ducts, bruising, swelling and severe skin reactions with blistering, aseptic meningitis, neutropenia, haemolytic anemia, renal toxicity

MORE INFORMATION:
What Xefo Rapid?
Active substance: LNX
Other ingredients are:
Core - microcrystalline cellulose, sodium bicarbonate, calcium phosphate dibasic anhydrous, low-substituted hydroxypropylcellulose, hydroxypropylcellulose, calcium stearate.
Film coat - titanium dioxide, talc, propylene glycol, hypromellose.