SINTROM. 4 mg. 20 tablets

SINTROM WHAT IS AND WHAT IT IS USED FOR ?
What is Sintrom ?
Sintrom is acenocoumarol ( acenocoumarol ) .
It is available in tablets of 4 mg.
Like most drugs Sintrom contain excipients except drug . If you are on a special diet or are allergic to certain substances , your doctor or pharmacist will advise you which of these substances can cause problems.
Sintrom tablets contain the following inactive ingredients: silica , magnesium stearate , starch , and lactose .
Atsenokumarolat belongs to a group of medicines known as anticoagulants. They reduce the ability of blood to clot , thus preventing the formation of clots in blood vessels.
Packing: tablets x 4 x 20 mg
 
What is it used Sintrom ?
Sintrom is used to prevent the formation of clots in blood vessels.

 
2 . BEFORE YOU TAKE SINTROM
You may take Sintrom only after consulting a doctor . Sintrom is not suitable for use in all patients.
You should not take Sintrom if:
you had any unusual or allergic reaction to acenocoumarol or other drugs with similar structure or any of the excipients of the tablets.
If you are not sure which drugs you should avoid , ask your doctor or pharmacist , you may not be strictly a treatment regimen (eg elderly patients without constant supervision , alcoholics or patients with mental disorders) ;
have a serious disease associated with bleeding (eg hemophilia ) or blood disorders with increased bleeding tendency ; have recently undergone eye surgery or brain surgery or another with serious blood loss (including dental surgery ) . This also applies to the operations of the lung , prostate, uterus , etc., in which there is increased activity of the fibrin - a protein playing an important role in blood clotting ; suffer from a stomach ulcer ; get gastro -intestinal tract or have bleeding into the brain ( stroke) , or into the lungs ; have an infectious disease of the heart ; uncontrolled high blood pressure; serious liver or kidney disease ; you are pregnant or have reasonable grounds to believe that you are pregnant .
Tell your doctor before you start taking Sintrom ® if:
 
have liver disease ;
have kidney disease or thyroid gland or tumors , infections or inflammations. They can affect the level of the drug from the drug in your blood ;
have severe heart disease ;
know that you are suffering from a lack of protein C or S ( various clotting factors ) ;
treatment plan , which can affect your tendency to bleed - eg , ambulatory surgery, tooth extraction , spinal puncture , or angiography.
Tell your doctor about all other medicines you are taking (see below) .
Drugs or substances that may affect the operation of Sintrom ®.
Tell your doctor or pharmacist about all medicines that you plan to take during the application of Sintrom . You may need to change the dosage or even stop one of the drugs . This applies to both the medicines available on prescription , and for those without a prescription.
Drugs that can increase the activity of Sintrom as allopurinol , anabolic steroids, androgens , anti-arrhythmics (e.g., amiodarone , quinidine ), antibiotics (e.g., erythromycin, tetracyclines , neomycin, chloramphenicol , and amoxicillin ) , clofibrate and the substances of this group , disulfiram , ethacrynic acid , glucagon , cimetidine, imidazole derivatives ( eg metronidazole and miconazole - even locally) , sulfonamides (including cotrimoxazole ) , sulphonylurea , thyroid hormones (including dextrothyroxine ) , sulfinpyrazone , tamoxifen and simvastatin .
Other drugs used for the prevention of blood coagulation (e.g. , heparin ) or affect platelet function ( blood elements involved in blood coagulation ) , such as salicylic acid or the like substances (e.g., aspirin , aminosalicylic acid , diflunisal ) , phenylbutazone or pyrazolone derivatives ( sulfinpyrazone ) and other NSAIDs .
Drugs that may reduce the effect of Sintrom ®, as aminoglutethimide , barbiturates , carbamazepine, cholestyramine, griseofulvin , oral contraceptives and rifampicin .
Hydantoin (a medicine used to treat epilepsy ) .
Sulfonylurea drugs ( drugs to lower blood sugar).
All drugs administered by intramuscular injection . If you are taking Sintrom ® or similar drugs , muscle injections should be avoided because it can cause hematomas .
Avoid the consumption of large amounts of alcohol . Excessive consumption of alcohol can affect the way of Sintrom ®. You should not consume alcohol regularly and not take more than one to two drinks once. If you have any questions, consult your doctor.
 
Other measures for the safe use
If pregnant or breast-feeding
Sintrom not take during pregnancy . Sintrom , like other anticoagulants, can seriously harm your baby. It is important to tell your doctor if you are pregnant or planning pregnancy . If you are in fertile age , your doctor may place a pregnancy test to rule out this possibility.
He may advise you to take measures against becoming pregnant while taking Sintrom .
If you are breastfeeding , you may take Sintrom . As a precaution , your doctor may prescribe your baby vitamin K. "
 
In children and elderly patients
If you are over 65 years of age , you may be more sensitive to the effects of Sintrom and that require more frequent checkups . Experience with Sintrom in children is limited .
 
When driving or operating machinery
Sintrom not affect your ability to drive or operate machinery. In case of accident , notify your doctor or hospital staff that you are taking Sintrom . Always wear personal anticoagulation card ( identification card , which noted that taking this medicine).
 
3 . HOW TO TAKE SINTROM ?
Dosage and duration of treatment with Sintrom be determined by your doctor. Will regularly conduct blood tests to determine what is the speed of blood clotting . This will help your doctor to determine the daily dosage Sintrom that you should take .
What is the usual dose ?
The usual dose is from 4 to 12 mg every other day , 4 to 8 mg every second day and then from 1 to 8 mg daily as a maintenance dose . Sensitivity to anticoagulants is individual and can not be changed during treatment or when changing your diet , especially if you include foods rich in vitamin C. Your doctor should periodically monitor your improvement and to adjust the dose according to your individual needs. Strictly follow your doctor's recommendations . No sudden discontinuation taking the medicine or change the dosage on their own initiative .
It is desirable to take the tablets every day at the same time (eg, evening meals with a glass of water).
Tell your doctor , dentist or pharmacist each time you visit that you are taking this medicine.
 
What to do if you miss a dose ?
If you miss a dose Sintrom , take it as soon as you remember. If it is almost time for your next dose , skip the missed again and continue your regular dosing schedule . Do not take double the dose. In the next review , tell your doctor about all missed doses .
 
overdose
Sintrom overdose can cause bleeding. If this happens , the intake of Sintrom should be discontinued and appropriate therapy . Tell your doctor immediately .
 
4 . WHAT ARE THE POSSIBLE SIDE EFFECTS OF SINTROM ?
Sintrom , like all drugs , unless the beneficial effects can cause some side effects . Although not all of these reactions are common in occurrence , they may require medical advice. The most common side effect is bleeding.
Immediately consult your doctor in case of any of the following symptoms of bleeding. In these cases, your body is likely to take a higher dose than necessary : unexplained nose bleeds or bleeding gums when brushing teeth ; bruising ; abnormally heavy bleeding from cuts or wounds ; unusually heavy or unexpected menstrual bleeding; blood in the urine ; bloody or black colored stools ; bloody sputum or vomiting blood ; sudden , severe headache or continuous .
Immediately consult with your doctor and the occurrence of any of the following side effects:
very rare
Bruises and blisters on the skin with or without scarring , usually on the thighs, buttocks , abdomen , chest, sometimes on the toes ; bruising or bleeding under the skin (possible signs of vasculitis) ; yellowing of the eyes or skin ( possible signs of liver damage ) .
Most side effects will go away without discontinuation of treatment. Visit your doctor if any of these symptoms persist for a long time or your cause suffering :
rare
Allergic reaction in the form of a skin rash or itching; unusual hair loss ; lack of appetite ; vomiting ; nausea .
If you notice any side effects not listed in this leaflet , ask your doctor or pharmacist.
 
 
5 . STORAGE SINTROM
Shelf life : 5 years from date of manufacture.
Do not use after the expiry date stated on the packaging.
Keep out of reach of children; uncontrolled use of this medicine may harm them .
 
6 . OTHER INFORMATION
It is important to take your medicine exactly as your doctor predpisnieto to achieve the best results and to reduce the risk of adverse reactions- .