RYTMONORM 300 mg. 20 tablets

Mode of action
Rytmonorm 300 mg is antiarrhythmic local-anesthetic main action and membrane stabilizing effect on myocardial cell.
Rytmonorm 300 mg prevents the formation and conduct of excitement in the atrium and kamerite.Na this is due to its pronounced effect on heart rhythm disorders of different origin.
 
 
Indications
Symptomatic and requiring treatment tachycardiac supraventricular cardiac arrhythmias such. AV-nodal tachycardia, supraventricular tachycardia in WPW-syndrome or paroxysmal atrial fibrillation.
Tezhkostepenni symptomatic ventricular tachycardia rhythm disorders sartseto.ako at the discretion of the physician are life-threatening.
 
 
Contraindications
Propafenone should not be used in:
overt cardiac failure, cardiovascular shock, unless caused by heart rhythm disorder, disease reduction in heart rate during the first three months after myocardial infarction or in restricted cardiac function (left ventricular ejection volume <35%) than in patients with life-threatening ventricular arrhythmias of the heart, available high-sino-atrial, atrioventricular and vatrekamerni violations in the conduct of excitement heart syndrome sick sinus expressed low blood pressure expressed disturbances in electrolyte balance (eg. metabolic disorders of potassium) severe obstructive (caused by blockage) lung disease, myasthenia gravis, known hypersensitivity to the active substance propafenone.
 
 
Use during pregnancy and lactation
During pregnancy, especially during the first three mesetsa.kakto and during lactation, propafenone should be taken only at the express medical indication.
 
Adverse effects
 
Drugs can have with your basic actions and side effects. Side effects that have been observed at the time of treatment with propafenone, but which does not necessarily occur in every patient are mentioned below. Sometimes, especially at a high initial dosage may occur gastrointestinal disorders, such as loss of appetite, nausea, binge povrashtane.chuvstvo for palnota.zapek, dry mouth and bitter taste, fading of ushite.setivni violations visual disturbances and dizziness.
In elderly patients with reduced myocardial function from time to time may result in dysregulation of the circulation with a tendency to decrease in blood pressure, which is caused by a standing body or by prolonged standing.
Can lead to proarrhythmic effects in the form of change or enhance rhythm disorders sartseto.Tezi proarrhythmic effects also manifest as strong or slow heart beat, a breach in the conduct of excitement or heart rate. Possible worsening of heart failure. Rarely can lead to fatigue, headaches, mental disorders such as anxiety and confusion, anxiety, nightmares and sleep disturbances and disorders in the course of involuntary movements, allergic skin reactions (redness, itching, exanthema or urticaria), and seizure of bronchi in patients with an increased tendency to bronchospasm.
In some cases, after a high dose of propafenone was observed a decrease in libido and number of seminal events kpetki.Tezi resolve after discontinuation of therapy. Because treatment with propafenone may be vital, it should not be interrupted without medical advice in these adverse effects.
 
 
Interaction with other drugs
The effect of some medicines may be affected by concomitant use of other means. Therefore, consult your doctor if you use constantly, have recently used or want to consume another medicine simultaneously with drug debate here. Your doctor will kazhe.dali in these circumstances there is incompatibility between the two drugs or need to take some special measures napr.opredelyane new dose when using this drug. The concomitant use of drugs with local-anesthetic effect (eg. In pacemaker, surgical or dental procedures), and other drugs that cause a slow heart rate and / or the pumping ability of the heart (napr.betaretseptorni blockers , tricyclic antidepressants) should be given the possibility of increased therapeutic deystvie.Osven are described further increases in the plasma concentration of propranolol resp.nivoto blood, metoprolol, desipramine, cyclosporin and digoksin.V case for additional administration of propafenone observed a doubling of the plasma concentration of theophylline.
In the event of relevant phenomena of overdose should determine the plasma concentrations and, if necessary, to reduce the dose of prescribed medication. Increased plasma concentrations of propafenone have been reported with concomitant use of cimetidine, resp.hinidin. When concomitant administration of propafenone phenobarbital resp.rifampitsin can lead to a reduction in plasma concentration propafenonovata even in subtherapeutic niva.Vazmozhno interaction of propafenone with oral anticoagulants (potentiation of the action of anticoagulants). In these patients, it is recommended careful monitoring of coagulation.
 
 
Precautions for use
This drug may in normal dosage to change the possibility of responding to such stepen.che significantly affect upravpenieto vehicle and work with mashini.Tova true figure more prominently in concomitant use with alcohol.
 
 
Warning:
Therapy with propafenone may change pacing-and-senzing threshold of pacemakers. Pacemaker function should be checked and if necessary re-programmed.
 
 
Dosage
Establishment of individual maintenance dose should be done under medical supervision with frequent monitoring of ECG and blood pressure (initial phase of adjustment of the dose). In an extension of the QRS-range (above 20%) or a frequency-dependent QT-interval, the dose should be reduced or temporarily discontinued therapy to normalize elektrokardiogramata.Pri reduced liver and / or renal function, therapeutic doses can lead to accumulation .
Under the control of ECG and plasma concentration and these patients may be included therapy with propafenone.
Unless otherwise prescribed drugo.za phase adjustment and maintenance dose is recognized daily dose of 450-600 mg.koyato corresponds to 1 1 / 2-2 tablets in 1-2 single doses spread avnomerno throughout the day.
Sometimes it is necessary to increase the daily dose of 900 mg, respectively 3 tablets evenly distributed throughout the day in 3 single dozi.Pri certain exceptional cases this dose may be exceeded, but only under strict cardiac monitoring.
The data apply to patients with a body weight of about 70 kg.Pri patients with lower weight daily doses should therefore be reduced.
Propafenone should be dosed step, especially in the initial phase in the elderly or severely damaged heart muscle. Rising dose should be only in the 3-4 day interval.
Initiation of therapy with antiarrhythmic agents in ventricular arrhythmias requires careful medical supervision and should only be done with the facilities for emergency treatment and opportunity for monitor control. During therapy, at regular intervals, must be carried out checkups (napr.prez one month -Standard ECG resp.prez three months -holter ECG and ECG under load). When the deterioration of the individual parameters of the QRS-napr.udalzhavane interval, pecn.QT-range by more than 25% or PQ-yn-spaces after more than 50% of QT resp.udalzhavan is more than 500 milliseconds or increase in the number or severity of arrhythmias, therapy should be verified again.
In patients with significant left ventricular function restriction (<35%), resp.strukturni myocardial diseases, dosing should be especially careful, stapalovidno.V these cases the recommended therapeutic dose escalation is necessary to take only when they are already established pharmacokinetic "steady-state" relations; usually after about 5-8 days. Thereby reducing the risk of possible proarrhythmic effects in the initial phase of therapy in these patients.
 
 
List of excipients
Crosscarmeliose sodium, purified water, rnacrogo! 400, macrogol 6000, magnesium stearate, corn starch, hydroxypropyl methylcellulose, microcristalline cellulose, titanium dioxide (E171).
 
Method and duration of administration
Because of the bitter taste and surface anesthetic action of the active substance film-coated tablets should be swallowed unchewed and suspended, with some liquid after meals. The duration of therapy is determined by the doctor.
 
 
Expiration date
The drug should not be used after the expiry of the term indications of godnost.Msdicine means to store the myasto.nedostapno for children.
 
 
Home, and a maximum duration of drug action
After a rapid onset of drug action (after about 30 min.) Rytmonorm 300 mgdostiga its maximum effect after 2-3 hours. The effect lasts for more than 8 hours.