Methylprednisolone 16 mg. 20 tablets

What Methylprednisolone  and what it is used
Methylprednisolone is the active substance methylprednisolone hanger. It belongs to a group of medicines called corticosteroids. A substance similar to that emitted by the adrenal gland hormones known as glucocorticoids. It has strong anti-inflammatory and anti-allergic effect. Favorably affect manifestations of various diseases and conditions caused by inflammation and allergy.

Methylprednisolone corticosteroid is administered to treat the symptoms of:
rheumatic diseases (eg. ankylosing spondylitis, rheumatoid arthritis in adults and children, joint inflammation in psoriasis, gout, etc.);
Lupus (erythematosus), inflammation of the skin and muscles, etc. dermatomyositis;
seasonal and allergic rhinitis, allergies associated with medications, bronchial asthma;
some severe skin and eye diseases;
certain blood diseases;
ulcerative colitis and Crohn's disease (inflammation of the colon associated with ulceration and flowing with severe and persistent bloody diarrhea and cramps).
It shall also apply:
some cancers and transplant (grafting) of organs;
in patients who for various reasons adrenal glands do not produce sufficient amounts of hormones, so it is necessary that such can be delivered through the reception of their analogs.

2. What you should know before using Methylprednisolone 
Do not take Methylprednisolone dirk:
if you are allergic to methylprednisolone or any of the other ingredients of this medicine (listed in section 6);
if you have severe fungal infections, for example. involving the lung or esophagus.
Warnings and Precautions
Talk to your doctor or pharmacist before taking Methylprednisolone hanger.
Your doctor will determine the appropriate dose to treat your disease and how long you should take the drug. Strictly follow its instructions do not change the prescribed dose without explicitly be initiated by a physician.

It is particularly important to know that:
the side effects can be avoided or reduced if you take the lowest dose that has a healing effect in the shortest possible time;
the intake of this medicine should not be stopped abruptly as this can lead to deterioration and recurrence of the disease;
normal release of hormones from the adrenal gland is suppressed in a longer term treatment. To allow the adrenal glands to restore its function, the daily dose should be reduced gradually. Your doctor will give you specific instructions on how to do this.
It is important to know also that:
when corticosteroid treatment is increased susceptibility to infections, it is also possible to mask some signs of infection;
varicella (chickenpox) can occur very severe and lead to serious complications in people taking corticosteroids for long periods as they suppress immunity. It is therefore necessary to avoid contact with sick chickenpox, shingles or measles (measles);
It should be avoided use of vaccines. If it is imperative that a consultation with relevant specialist;
in patients with a hidden occurring undetected tuberculosis or those with a positive tuberculin test (Mantoux etc.) is required strict medical supervision to avoid reactivation of the disease;
administration of methylprednisolone may lead to deterioration of diseases caused by parasites, eg. in enterobiosis (a disease caused by parasites known as pinworms).
Tell your doctor before starting treatment if you suffer or have suffered from:
Osteoporosis (reduced bone density and increased susceptibility to fractures);
hypertension, heart failure (heart disease, which can lead to fatigue, shortness of breath, swelling of the ankles), recent myocardial infarction;
diabetes;
glaucoma (increased eye pressure);
liver diseases (incl. cirrhosis), kidney, stomach and intestine (especially gastric ulcer);
epilepsy, mental illness;
ocular herpes, tuberculosis, abscess, other purulent infections;
myasthenia gravis;
underactive thyroid gland;
You need to know, and your relatives to be informed that treatment with corticosteroids may develop psychiatric disorders. Most often this occurs a few days to a few weeks after starting treatment. Most of them disappear completely or after dose reduction or upon discontinuation of treatment. This does not remove the need to use a specific treatment.
If a feeling of depression, anxiety, insomnia, lack of motivation, thoughts of harming needed immediately to share this with your partner and look consulting a medical professional.
Steroids can lead to growth failure in children and adolescents, so treatment should be limited to the lowest possible dose and shortest period of intake.
In older patients often can be observed some side effects (osteoporosis, diabetes, high blood pressure, susceptibility to infections) and they have a more serious course, which is why they need intense supervision by a doctor.

Other medicines and Methylprednisolone dirk
Tell your doctor or pharmacist if you are using, have recently used or might use other drugs.
Some drugs accelerate the degradation of corticosteroids and thus tend to reduce their effect. These are rifampicin and rifabutin (antibiotics used to treat tuberculosis), carbamazepine, phenobarbitone, phenytoin (medicines to treat epilepsy).
Others, such as cimetidine (used to treat heartburn), the antibiotic erythromycin, antifungal antibiotics, ketoconazole, itraconazole, can reduce the degradation of Corticosteroids and thus lead to enhancement of their effects.

Corticosteroids can:
reduce the effects of drugs used to treat diabetes (incl. insulin), high blood pressure, diuretic (increase urine output);
enhance the effect of coumarin anticoagulants (drugs to reduce blood clotting) and medications containing salicylates.
Convulsions have been reported with concomitant administration of methylprednisolone and cyclosporine (reduces the risk of rejection after organ transplantation).
If you take digoxin (to treat heart disease) requires periodic monitoring by a physician, as may occur disturbances in the water-salt metabolism and loss of potassium.

Methylprednisolone dirk food, beverages and alcohol
During the treatment with this medication should be consumed fruit juice and grapefruit, as the degradation of methylprednisolone from the liver is increased, and this can lead to a weakening of the therapeutic effect.

Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine.

pregnancy
Methylprednisolone passes through the placenta. It is known that in animals can cause certain birth defects (eg. 'Wolf' mouth) and slow brain growth and development.
There is not enough evidence that corticosteroids lead to similar effects in humans, but during pregnancy these drugs may be used only after medical assessment that the benefit outweighs the risk to the fetus and newborn.

breastfeeding
Corticosteroids are excreted in small amounts in breast milk. Breastfeeding they should apply only after an assessment by a doctor.

Driving and using machines
No evidence of adverse effects on the ability to drive and use machines.

Methylprednisolone hanger contains lactose monohydrate
The composition of the product as an excipient includes lactose. This makes it unsuitable for people with congenital intolerance to some sugars (lactase deficiency, galactosemia or glucose / galactose malabsorption syndrome).
If your doctor tells you that you have such intolerance should not take this product.

3. How to take Methylprednisolone dirk
Always use this medicine exactly as your doctor or healthcare professional. If you're not sure, ask your doctor or pharmacist.

Adults
The daily dose, route and frequency of administration, duration of treatment will be determined by your doctor according to the type of disease, its severity and course.
The daily dose can be administered daily in one or several doses or as a single but double dose during the day.
It is recommended that the daily intake of the drug going in the hours around 8.00 am. The tablet can be divided into equal doses.
Adverse effects can be reduced by using the lowest effective dose for the shortest possible period.
In most cases, treatment is started with a higher dose, which after some time can be reduced or increased, depending on the effect achieved.
You need to know that the termination of the medicine in any case should not be done abruptly.
children
The dose is determined at the discretion of the physician. If it is possible, the drug should be administered as a single dose every other day, and the treatment is done by applying the lowest dose for the shortest period of time.

Elderly
The daily dose, route and duration of administration must be consistent with that in adults side effects are more common and sometimes serious.

If you take more dose Methylprednisolone dirk
In acute overdosage with methylprednisolone not observed any specific events. Chronic overdose observed accumulation of fat in the face, abdomen and hips, stretch marks, redness of the cheeks and others. If you take a higher dose of the designated contact for advice your doctor.

If you forget to take Methylprednisolone dirk
If you forget to take a dose, do it as soon as possible after you remember. Do not take a double dose to make up for the forgotten. Apply the next dose at the usual time.

If you stop taking Methylprednisolone dirk
Do not stop treatment unless your doctor tells you this, even if you feel better. Remember that the cessation of treatment in any case should not be done abruptly but should be by gradual reduction of the daily dose.
If you suddenly stop taking the product may occur etc. Withdrawal symptoms (see section 4).

If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.

Adverse reactions which may occur in the treatment with this medication are:
Common side effects (affects less than 1 in 10 patients):
increased susceptibility and severity of the course of infection, masking their clinical manifestations overlay additional infections;
rounding of the face and persistent redness in the cheeks (moon face), excessive hair growth, weight gain;
retention of sodium and water;
increased excitement and nonchalance (euphoria), depression and anxiety;
cataract (eye cataracts);
high blood pressure;
stomach ulcers, sometimes leading to bleeding;
thinning of the skin and acne;
muscle weakness;
retention of growth in children and adolescents;
disrupted, delayed wound healing;
low levels of potassium in the blood.
Uncommon side effects (affects less than 1 in 100 patients):
low blood pressure;
blood clots.
Not known (from the available data can not be estimated):
activate "sleeping" TB;
increase in white blood cells;
different weight allergic reactions;
need for higher doses of the drugs used to treat diabetes;
irritability, mood swings, thoughts of self-harm, hallucinations, changes in behavior, agitation, anxiety, confusion;
memory loss, sleep disturbances, seizures, headache, dizziness;
heart failure (heart disease, which can lead to fatigue, shortness of breath, swelling of the ankles and the like.);
elevated intraocular pressure (glaucoma), optic nerve damage, thinning and rupture of the cornea and sclera, exacerbation of ophthalmic viral or fungal infections, permanent protrusion of the eyeball;
acids and heartburn, nausea, bloating, ulcers of the intestine or esophagus, fungal infection of the esophagus, acute inflammation of the pancreas;
formation of stretch marks, extension of skin blood vessels, pinpoint hemorrhages in the skin and mucous membranes;
menstrual irregularities, complete lack of a monthly cycle;
thinning, thinning bones and a tendency to spontaneous fractures (osteoporosis) of the vertebrae and long bones, rupture of tendons, muscle weakness, muscle damage;
elevation of some laboratory parameters;
inhibition of the reaction in skin tests;
suppression of the adrenal glands, growth retardation in infants, children and adolescents.
Withdrawal symptoms
Rapid dose reduction in long-term treatment can lead to acute adrenal insufficiency, significant reduction in blood pressure and death. In "withdrawal syndrome" can also be observed fever, aching muscles and joints, fever, conjunctivitis, painful itchy skin nodules and weight loss.

If any of the side effects gets serious, or get any side effects not listed in this leaflet, please ask your doctor or pharmacist.
5. How to store Methylprednisolone dirk
At temperatures below 25 ° C
Shelf life after first opening of the bank - four (4) months.
Keep out of reach of children.
Do not use Methylprednisolone hanger after the expiry date stated on the carton. The expiry date refers to the last day of that month. Do not use Methylprednisolone hanger if you notice changes in the appearance of the tablet.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer use. These measures will help to protect the environment.

6. Contents of the pack and other information
What Methylprednisolone dirk
The active substance in one tablet is: methylprednisolone (methylprednisolone) 16 mg.
The other ingredients (excipients) are: lactose monohydrate / corn starch (85:15), colloidal anhydrous silica, magnesium stearate.

Methylprednisolone hanger looks like and contents of the pack
Round, flat tablets with bevelled and scored on one side, diameter of 13 mm.
10 (ten) number of tablets in blister transparent orange PVC / PVDC / Al foil. Two blisters in a box.

40 (forty) number of tablets in white, opaque plastic Bank closed with a protective cap ring. A bank in a cardboard box.

100 (one hundred) the number of tablets in white, opaque plastic Bank closed with a protective cap ring. A bank in a cardboard box.

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