KONKOR AM. 5 mg. / 5 mg. 30 tablets

KONKOR AM WHAT IS AND WHAT IT IS USED

Konkor AM tablets are used to treat high blood pressure, as replacement therapy in patients adequately controlled with separate products administered concurrently at the same dose as in combination, but as separate tablets.

 BEFORE YOU TAKE KONKOR AM

Do not take Konkor AM

 If you are allergic (hypersensitive) to amlodipine, bisoprolol (drugs), dihydropyridine derivatives or to any of the excipients of Konkor AM;

 If you have severe narrowing of the outlet of the left ventricle (eg high grade aortic stenosis);

 If you suffer from acute heart failure, unstable heart failure after acute myocardial infarction or heart failure requiring intravenous medications to increase the strength of myocardial shortening;

 If you are suffering from shock due to impaired function of the heart (in such cases, blood pressure is very low and close to the circulatory collapse);

 If you suffer from heart disease, which is characterized by a very slow heartbeat or irregular contraction of the heart (second or third degree atrioventricular block, sinoatrial block, sick sinus syndrome);

In the case of extremely low blood pressure (the upper limit is consistently less than 100 mmHg);

 In case of severe bronchial asthma or chronic obstructive pulmonary disease;

 In case of severe peripheral arterial disease;

 In case of Raynaud's syndrome, characterized by numbness, tingling and discoloration of the fingers and toes exposed to cold;

 In the case of untreated pheochromocytoma, a rare tumor that is the core of the adrenal glands;

 These metabolic conditions in which blood pH is acidic.

If you think you suffer from any of the above conditions, ask your doctor whether you should take this medicine.

Take special care with Konkor AM

Konkor AM can be used, but with caution in the following conditions, which is why you should inform your doctor if any of the following apply to you:

 Elderly;

Heart failure;

 Diabetes with highly variable blood sugar levels;

 Strict diet;

 Concomitant antiallergic (desensitization) treatment (eg to prevent allergic rhinitis);

 A slight disorder of the excitatory-wire system to regulate heart rhythm (first degree AV-block);

 Violation of coronary perfusion (Prinzmetal's angina);

 Vascular diseases of the extremities, characterized by reduced perfusion;

 Psoriasis;

 Hyperthyroidism;

 Liver or kidney disease;

 In the case of treated pheochromocytoma, a rare tumor that is the core of the adrenal glands;

 Bronchial asthma or other chronic obstructive pulmonary diseases;

 If you have surgery, tell your anesthetist that you are taking Konkor AM.

Your doctor may consider it necessary to do something extra (eg adding a pharmacological treatment), if there is any of the above conditions.

Taking other medicines

Therapeutic effects and side effects of the drug can be affected by other drugs being taken concurrently. Interactions can occur even if other medication has been taken for a short time.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Concomitant use of these drugs Konkor AM is not recommended:

 Calcium channel blockers of the verapamil and diltiazem type: These medicines are used to treat high blood pressure and chronic stable angina;

 Centrally acting antihypertensives (eg clonidine, methyldopa, monoksidin, rilmenidine): Do not stop taking this medication without first consulting your doctor.

The following medicines may be used together with Konkor AM under certain circumstances with caution under medical supervision:

 Some medicines affect heart rhythm (quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone, amiodarone). These medicines are used to treat irregular or abnormal heart rhythm

 Local blockers agents (eg eye drops used to treat glaucoma);

 Parasympathomimetics. These medicines are used to potentiate the function of smooth muscle in diseases of stomach, intestines, bladder and glaucoma;

 Insulin and oral antidiabetic agents;

Hypnotics, anesthetics;

 Cardiac glycosides (digitalis), medicines used to treat heart failure;

 Nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs can be administered to treat joint inflammation, pain or arthritis;

 Sympathomimetic agents (eg isoprenaline, dobutamine, norepinephrine, epinephrine). These medicines are used to treat severe circulatory disorders emergency;

 All medicines that lower blood pressure due to therapeutic or adverse effects (eg antihypertensives, tricyclic antidepressants, barbiturates, phenothiazines).

During concomitant use of these drugs Konkor AM should be taken into account:

 Mefloquine, used to prevent or treat malaria;

 Monoamine oxidase (MAO) inhibitors (except MAO-B inhibitors) used to treat depression;

 Drugs affecting the metabolism of amlodipine and bisoprolol (eg rifampicin, ketoconazole, itraconazole, erythromycin, ritonavir, St John's Wort)

 Ergot derivatives (medicines used to treat bleeding gynecological origin).

Taking Konkor AM tablets with food and drink

Alcohol may increase blood pressure by reducing the effect of Konkor AM.

Pregnancy and lactation

Ask your doctor or pharmacist before taking any medicine.

Given that there is not enough clinical experience for pregnant women, it can be applied only after careful individual benefit / risk ratio of a doctor, so be sure to tell your doctor if you are pregnant or planning to have a baby .

In case of application in pregnancy may be necessary to carefully monitor the condition of the fetus and newborn.

The decision on whether to continue / discontinue breast-feeding or to continue / discontinue therapy with Konkor AM should be taken given the benefit of breastfeeding to the child and the benefit of therapy for the mother Konkor AM.

Driving and operating machinery

Konkor AM may violate the above abilities, causing dizziness, headache, fatigue or nausea - especially when starting treatment or if treatment changes, and alcohol - because the physician decides what dose individually when you can drive or operate machinery.

 HOW TO TAKE KONKOR AM

Always Konkor AM exactly as your doctor has told you. You should consult with your doctor or pharmacist if you are unsure.

The usual dose is one tablet of a given concentration. Konkor AM tablets should be swallowed with or without food, with some liquid, without chewing.

Depending on the effect, your doctor may increase the starting dose to a combination of other concentrations.

Usually there is no need dose adjustment in mild to moderate hepatic and renal disease.

In severe liver or kidney disease dosage may be changed.

Do not stop taking your medicine arbitrarily.

Elderly

No need for dose adjustment in these patients, but caution is advised when increasing the dose.

Children and adolescents

Konkor AM tablets are not recommended for use in children under the age of 18 years due to insufficient data on safety and efficacy.

If you think that the therapeutic effect of AM Konkor tablets are too strong or too weak, talk to your doctor or pharmacist.

If you take more than the dose Konkor AM

If you take more Konkor AM tablets than you should consult a doctor immediately.

If you forget to take Konkor AM

Try to take the missed dose as soon as possible. If it is already time for your next dose, do not take a double dose to make up for a missed dose, because it can not compensate for lost volume, but will be exposed to the risk of overdose.

If you stop taking Konkor AM

Do not stop taking this medicine suddenly or alter the recommended dose before consulting your doctor, as in such cases, heart failure may temporarily worsen. Treatment should not be stopped abruptly, especially in patients with coronary artery disease. If it is necessary to stop the treatment, the dose should be reduced gradually.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

 POSSIBLE SIDE EFFECTS

Like all medicines, Konkor AM can cause side effects, although not everybody gets them.

If any of these side effects, ask your doctor or pharmacist.

Common side effects (affects 1 to 10 users in 100):

Headache, dizziness, drowsiness (especially at the beginning of treatment), palpitations, flushing, abdominal pain, swelling of ankles, swelling, fatigue, feeling cold and numbness, gastrointestinal complaints such as nausea, vomiting, diarrhea, constipation.

Uncommon side effects (affects 1 to 10 users in 1000):

Insomnia, mood (including anxiety), depression, temporary loss of consciousness (syncope), hypoesthesia, paresthesia, abnormal taste (dysgeusia), tremor, visual disturbance (including diplopia), tinnitus, hypotension, dyspnea, rhinitis, changes in bowel habits (including diarrhea and constipation), dry mouth, dyspepsia, alopecia, small hemorrhages in the skin and mucous membranes (purpura), skin discoloration, increased sweating, itching, rash, exanthema, arthralgia, muscle pain, muscle cramps, back pain, frequent urination, micturition disorder, nocturia, impotence, breast enlargement in men, chest pain, asthenia, pain, malaise, weight gain, weight loss, sleep disturbances, cardiac conduction worsening of pre-existing heart failure, slow heartbeat (less than 50 bpm), hypotension, bronchospasm in patients with bronchial asthma or a history of obstructive lung disease, muscle weakness and cramps, fatigue *.

 These symptoms especially occur at the beginning of therapy. They are usually mild and often disappear within 1-2 weeks.

Rare side effects (affects 1 to 10 users in 10,000):

Confusion, increased natriglitseridite, nightmares, feelings of illusion, which is unusual sense without notice incentive, like a true feel and look real (hallucinations), reduced tear secretion (must be taken into account if you wear contact lenses), disability hearing, allergic rhinitis, hepatitis, hypersensitivity reactions such as itching, redness, rash, elevated liver enzymes.

Very rare side effects (affects less than 1 in 10,000):

Reducing the number of leukocytes and platelets, allergic reactions, increased blood sugar, hypertension, peripheral neuropathy, stroke, cardiac arrhythmia, and areas of inflammation in the small blood vessels (vasculitis), cough, gastritis, gingival hyperplasia, pancreatitis, jaundice, acute swelling of the skin or mucous membrane, including the most common eyelid, lip, joints, genitals, glottis, pharynx and tongue (angioedema), severe inflammation of the skin or mucous membrane vesicles with red (erythema multiforme), urticaria, erythema and widespread scaling of the skin (exfoliative dermatitis), serious damage to the skin and mucous membranes of the mouth, genitals and anus with formation of blisters with fever, sore throat and fatigue (Stevens-Johnson syndrome), sensitivity to sunlight, conjunctivitis, drugs with a similar mechanism of action compared with bisoprolol (active ingredient of the preparation), may cause or aggravate psoriasis (a chronic skin with itchy, scaly red patches) or can cause psoriasis-like skin disease.

If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

 HOW TO STORE KONKOR AM

Do not store above 30 ° C. Store in original container.

To protect from light.

Do not use Konkor AM tablets after the expiry date stated on the carton (year / month). The expiry date refers to the last day of that month.

Keep out of reach of children.

Do not use Konkor AM if you notice symptoms (discoloration) of deterioration.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of your quantities of the drug. These measures will help to protect the environment.