Karbis 8 mg. 28 tablets

WHAT IS KARBIS AND WHAT IS USED FOR?
Carbis belongs to a group of medicines known as angiotensin II receptor antagonists. Angiotensin-II is a substance produced in the body that binds to receptors in the blood vessels, causing them to contract. This leads to an increase in blood pressure. Carbis prevents the binding of angiotensin-II to these receptors, causing blood vessels to relax, and blood pressure decreases.
Carbis is used to treat high blood pressure (hypertension) and to treat some types of heart failure.

2. BEFORE YOU TAKE KARBIS
Do not take Karbis
- If you are allergic (hypersensitive) to candesartan cilexetil or any of the other ingredients of Carbis
- If you are more than 3 months pregnant. (It is also good to avoid Carbis at the beginning of pregnancy - see Pregnancy Point),
- If you have severe liver disease.
- Take special care with Carbis If you have severe vomiting or diarrhea,
- If you have heart problems, If you have kidney problems,
- If you are going to have any surgery or an anesthetic, you should tell your doctor that you are taking Carbis,
- You should tell your doctor if you think you are pregnant (or may be) pregnant. Carbis is not recommended in early pregnancy and should not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used during this period (see Pregnancy). If you are breast-feeding or intend to breast-feed, you should tell your doctor.

Pregnancy and breastfeeding
Talk to your doctor or pharmacist before taking any medicine.

Pregnancy
You should tell your doctor if you think you are (or may be) pregnant. Your doctor will usually advise you to stop taking Carbis before you become pregnant or as soon as you know you are pregnant and will advise you to start taking another medicine instead of Carbis. Carbis is not recommended in early pregnancy and should not be taken when you are more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.

Breastfeeding
Tell your doctor if you are breast-feeding or intend to breast-feed. Carbis is not recommended for mothers who are breast-feeding and your doctor may choose another treatment for you if you want to breast-feed, especially if your baby is newborn or was born prematurely.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Blood tests may be necessary if you take:
• Potassium supplements,
• Potassium-containing salt substitutes,
• Potassium-sparing medicines that increase the amount of urine (diuretics), Other medicinal products that may increase potassium levels (eg heparin),
• ACE inhibitor,
• Non-steroidal anti-inflammatory drugs
• or lithium-containing medicines.
The effect of candesartan cilexetil may be reduced when taking non-steroidal anti-inflammatory drugs (eg ibuprofen).

Take Karbis with food and drink
Karbis can be taken with or without food.

Driving and using machines
No studies on the effects on ability to drive and use machines with Carbis have been conducted, but Carbis is unlikely to affect your ability to drive or use machines. However, dizziness or fatigue may occasionally occur during treatment of high blood pressure. If you have these symptoms, you should consult your doctor before driving or using machines.

Important information about some of the ingredients in Carbis
Carbis contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this product.

3. HOW TO TAKE KARBIS?
Always take Carbis exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. There are other concentrations available that may be more appropriate for your dosing schedule.
Carbis is taken orally and can be taken with or without food once a day. You should try to take your daily dose at the same time each day. It is important to continue taking the tablets until the treating physician tells you otherwise.
Adults: The usual dose is 8 mg once a day. The dose may be increased to 32 mg once a day depending on the blood pressure response.
The maximum blood pressure lowering effect should be achieved 4 weeks after the start of treatment.
Children: Carbis is usually not recommended for children (Patients with kidney problems: The doctor may recommend a lower dose, especially when starting treatment.
Patients with liver problems: The physician may recommend a lower dose,
Very rare: affects less than 1 user in 10,000
Not known Frequency can not be predicted from available data
As with other medicines, very rare cases of allergic skin reactions (rash, urticaria) and localized swelling of the face, lips and / or tongue have been reported in patients receiving candesartan cilexetil. If you think you have developed such a reaction or have difficulty in breathing, stop taking Carbis and seek immediate medical attention.
The following undesirable effects have been reported in patients with high blood pressure during clinical trials:
Common: chills or flu-like symptoms, dizziness / vertigo and headache.
In patients with heart failure *, the following additional side effects have been reported in clinical trials:
Common: low blood pressure, increased blood potassium levels and kidney problems.
Adverse reactions reported since candesartan cilexetil have been marketed are:
Very rare side effects: headache, dizziness, decreased white blood cell count, nausea, joint and muscle pain, liver function abnormalities, renal dysfunction, increased potassium levels in the blood, decreased blood sodium levels.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist

5. HOW TO STORE KARBIS?
Keep out of the reach and sight of children.
Do not use Karbis after the expiry date which is stated on the carton
The expiry date refers to the last day of that month.
This medicinal product does not require any special storage precautions.
Medicines should not be disposed of via wastewater or household waste.

6. ADDITIONAL INFORMATION
What does Karbis contain?
The active substance is candesartan cilexetil (candesartan cilexetil). Each tablet contains 4 mg, 8 mg, 16 mg or 32 mg of candesartan cilexetil. The other ingredients are lactose monohydrate, maize starch, macrogol 8000, hydroxypropyl cellulose, carmellose calcium, magnesium stearate and red iron oxide (E172) - (8 mg, 16 mg and 32 mg tablets only)

What Karbis looks like and what the package contains
4 mg tablets are round, white, slightly biconvex, with a line divider on one side, with bevelled edges.
8 mg tablets are round, slightly pink, slightly biconvex, with a line divider on one side, with bevelled edges.
16 mg tablets are round, slightly pink, slightly biconvex, with a line on one side, with bevelled edges.
32 mg tablets are round slightly pink, slightly biconvex, with a line on one side, with bevelled edges.
The tablet may be; divided into two equal halves.
Boxes of 14, 28, 30, 56, 60, 84, 90, 98 tablets in blisters are available. Not all pack sizes may be marketed.

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