ISODINIT 10 mg. 60 tablets

WHAT ISODINIT AND WHAT IT IS USE Isodinit is a medicinal product from the group of nitrates. It causes dilation of the veins mainly by lowering their tone of smooth muscle, lowers pressure in the venous system, reducing venous return to the heart and ventricular filling. Affects arteries, leading to a reduction in systemic vascular resistance (afterload). So it improves heart function, relieves his work and reduced his needs oxygen. Thus preventing the occurrence of angina heart pain origin and improves cardiac function in chronic congestive heart nedostatachnost.Izodinit apply to:
• Prevention and treatment of angina pectoris.
• Concomitant treatment of congestive heart failure.

2. WHAT YOU NEED TO KNOW BEFORE ISODINIT
Isodinit not apply to:
• Hypersensitivity to the active substance or to any of the excipients.
• Acute circulatory failure, severe hypotension or hypovolemia (low blood pressure or decreased volume of circulating blood), collapse states shock.
• Acute myocardial infarction with low ventricular filling pressure.
• Expressed anemia.
• Recent brain injury and brain hemorrhage.
In the application of this product, please note the following:
Caution should be exercised and medical supervision during treatment with Izodinit in the following cases:
This product should be administered with caution in patients with hypothyroidism (underactive thyroid gland), hypothermia (cooling), malnutrition, severe hepatic and renal function.
It is possible to observe signs of circulatory collapse after the first dose, especially in patients with labile circulation. Some patients may develop orthostatic hypotension (sudden fall in blood pressure when standing up) and syncope (fainting due to a drop in blood pressure).
Careful use of this product in diseases accompanied by difficulty ventricular filling (pericardial tamponade, constrictive pericarditis, aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy), as it can enhance angina (painful) symptoms.
It is necessary to refine the application in conditions with increased intracranial pressure or glaucoma (increased eye pressure). When large doses can develop methemoglobinemia (a medical condition with elevated levels of reduced hemoglobin).
Taking Izodinit can change the results of some research (colorimetric determination of cholesterol).
After prolonged treatment with high-dose, discontinuation should be gradual in order to prevent the development of new anginal simptomatika.Pri non-recommended dosing interval may develop nitrate tolerance (reducing the strength of its medical action).

Tsrilozhenie of Izodinit and intake of foods and drinks:
No evidence of the need for special diets or restrictions on certain types of foods and beverages during treatment with this product.

BremennostPredi intake of any medicine, consult your doctor or lekuvagtsiya with farmatsevt.Tozi product not be used during pregnancy unless clearly necessary and after careful consideration of the benefit / risk ratio.
breastfeeding
Before taking any medicine, consult your doctor or farmatsevt.Poradi possible risk of harm to the infant, you need to decide or to discontinue breast-feeding or discontinuation of therapy with Izodinit.

Driving and using machines
Because of the potential for dizziness and drowsiness, the use of this product may impair the ability to drive and use machines.
Important information about some of the ingredients of Izodinit:
This medicinal product contains lactose as an excipient, which makes it unsuitable for patients with lactase neponosimost.Poradi presence in the composition of wheat starch, this product may be dangerous for people with gluten intolerance (celiac disease).
Taking other medicines:
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, even if they have not been prescribed by your doctor.

Concomitant use of alcohol and drugs that lower blood pressure, such as beta blockers, calcium channel blockers, vasodilators and others. may increase the hypotensive (especially postural) their efekt.Efektite of norepinephrine, acetylcholine, histamine and others. can be attenuated by concomitant use of nitrati.Simpatikomimetitsite can reduce the antianginal effects of nitrates. Nitrates may increase plasma levels of dihydroergotamine and strengthen its hypertensive effect.
3. HOW TO TAKE ISODINIT
Always Izodinit according to the instructions of the treating lekar.V according to the complaints, the doctor will determine the appropriate treatment for your disease doza.Tabletkite Izodinit be taken before meals, orally chewed along with sufficient technost.Preporachitelni doses for adults:
For prevention and treatment of angina, the usual starting dose is 10 mg (1 tablet). 3 times daily. The dose can vary from 30 to 120 mg (3-12 Table.) Per day, divided into 2 to 3 doses, according to the needs of the patient and the doctor's judgment. In individual cases, can be administered up to 240 mg daily, without this being associated with serious side effects, but it is preferred the formulation with a higher concentration and prolonged release of the drug substance. In order to achieve maximum therapeutic effect is recommended that the individual titration of the drug to the needs of the patient, his response and tolerability. At each dose regimen, in order to prevent the development of nitrate tolerance is necessary to provide a 10-12 hour beznitraten interval (usually at night, when the patient rests).
As concomitant treatment of congestive heart failure - 30-160 mg (3-16 table.) Daily, divided into four times or according to individual needs. In these patients is essential, careful monitoring of cardiovascular function in determining individual dosage.
Children - This product is not recommended for children. Their effectiveness and safety is not dokazana.Ako have the impression that the effect of the application of Izodinit is stronger than expected you insufficient, contact your doctor or pharmacist.
Symptoms of overdose include lowering blood pressure <90 mmHg, pallor, sweating, weak pulse, palpitations, dizziness upon standing, headache, fatigue, nausea and vomiting.
Of high therapeutic doses may occur paradoxical effect -vloshavane blood flow in the vessels of satseto and provoking angina pain krizi.Visoki doses cause: redness of the lips, nails, palms of the hands; feelings of restlessness, tension; shortness of breath, fatigue, weakness; vomiting; double vision; palpitations, low blood pressure, syncope, convulsions; rarely cyanosis, methemoglobinemia, difficulty breathing and slow heartbeat, fever. At very high doses may increase intracranial pressure occurrence of cerebral symptoms.
In cases of severe poisoning with tablets should be gastric lavage. In methemoglobinemia apply slow intravenous methylene blue, vitamin C, need hemodialysis. Normal blood flow may be maintained by placing the patient in a horizontal position, the oxygen supply, infusion of plasma or suitable electrolyte solutions. When data to stop breathing or heart activity began immediate resuscitation meropriyatiya.Pri signs of symptoms of overdose, immediately contact a doctor! If you forget to use Izodinit If you miss a dose, take it at the next regular intake without increasing the dose.

4. POSSIBLE SIDE EFFECTS
Like all medicines, Isodinit can cause adverse reaktsii.Nay commonly observed adverse reaction when taking Izodinit (with a frequency> 10%) is headache. Headaches, in most cases, gradually reduced after a few days, but can be severe and hard. It can often be controlled by lowering the dozata.V beginning of the treatment, as well as increasing the dose occur relatively frequently (1-10%), hypotension (low blood pressure) and / or dizziness. These symptoms, they can be accompanied by dizziness, drowsiness, palpitations and fatigue.
Rarely (with an incidence of less than 1%) were observed nausea, vomiting, flushing of the face, skin allergic reactions. In isolated cases may develop more severe forms of skin reactions (exfoliative dermatitis, Stevens-Johnson or angioedema).
Reflex tachycardia may occur as a result of compensatory reaction resulting reduction in systemic blood pressure. In very rare cases can develop collapse condition with arrhythmias and bradycardia (slow heartbeat). In some cases - a paradoxical reaction-amplified pain of angina attacks.
Very rarely - nausea and vomiting
With continued use, and more often in high doses, can develop tolerance to the drug substance (weakening of the therapeutic effect with a loss of the antianginal and anti-ischemic activity in some patients). A slight increase in intraocular pressure were seen in patients with zatvorenoaglova glaukoma.Ako notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

5. Storage
Keep out of reach of children! At temperatures below 25 ° S.Da not use after the expiry date stated on the package! Shelf life: five (5) years from date of manufacture.