INDAPEN SR 1.5 mg. 30 tablets

WHAT Indapen SR AND WHAT IT IS USED
Indapen SR belongs to a class of drugs called "diuretics" which increases the flow of urine from the kidneys.
Used to treat high blood pressure / essential hypertension /.

2. BEFORE YOU TAKE Indapen SR
Do not take Indapen SR:
If you are allergic / hypersensitive / indapamide or to any of the excipients of this medication;
If you are allergic / hypersensitive / to other drugs of the same chemical class as indapamide / "sulfonamides" / eg trimethoprim or co-trimoxazole;
If you suffer from severe kidney disease;
If your doctor told you that you have low potassium levels in the blood.
Be careful when taking Indapen SR
Tell your doctor before taking this medicine if you are suffering or have suffered from:
Heart disease, heart failure or heart rhythm problems;
Diabetes / watch regularly the level of sugar in the blood /;
Gout;
Kidney disease;
Liver diseases.
Indapen SR affect levels of potassium and sodium in the blood. Your doctor may order blood tests to monitor levels of potassium and sodium in the blood before and during treatment. This is particularly important for patients who are at high risk of developing electrolyte imbalances / elderly, patients taking many medications or who are malnourished /.
Indapen SR may enhance the sensitivity of the skin to sunlight. If this happens, you should inform your doctor as he / she may decide to stop treatment. In applying Indapen SR is recommended to protect exposed to sunlight or artificial UV-radiation areas.
If you need to examine the function of the parathyroid gland, tell your doctor, who will suspend treatment Indapen SR.
Athletes should be aware that Indapen SR can give a positive reaction in doping tests. If you think that such a situation may apply to you or you have any questions or concerns about taking this medicine, consult your doctor or pharmacist.

Taking other medicines:
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines without a prescription.
The effect of Indapen SR may change or occur side effects if you are taking the following medicines. Consult your doctor before taking the following medicines:
Combinations not recommended:
Lithium / used in the treatment of depression /: should not take Indapen simultaneously with lithium due to the risk of increased levels of lithium in blood with signs of overdose.
Combinations requiring precautions:
These medicines can cause Torsade de pointes (special form of heart rhythm problems):
Medicines to treat irregular heartbeat, such as quinidine, hidrokvinidin, disopyramide, amiodarone, sotalol, dofetilide, ibutilide;
Drugs for the treatment of psychosis, such as chlorpromazine, tsiamemazin, levomepromazine, thioridazine, trifluoperazine, amisulpride, sulpiride, sultopride, tiapride, droperidol, haloperidol;
Various other drugs such as bepridil / used for the treatment of angina /, and cisapride diphemanil / used for the treatment of gastrointestinal problems /, intravenous erythromycin, pentamidine, moxifloxacin, sparfloxacin / used to treat infections / halofantrine / used for the treatment of malaria / mizolastine / used for the treatment of allergy / intravenous vincamine / used for the treatment of circulatory problems in the brain /.
Non-steroidal anti-inflammatory drugs / NSAIDs known / used for treating pain and inflammation / eg ibuprofen, diclofenac, and indomethacin / including selective inhibitors of COX-2 / COX-2 / / as Celecoxib, Etoricoxib / or high doses of aspirin / or 3 g more a day /:
Possible reduction of the effect of SR Indapen to reduce blood pressure. Risk of acute renal failure in patients with reduced water content in the body / dehydration /. Taking adequate hydration is vital.
ACE-inhibitors used to treat high blood pressure and cardiac insufficiency / eg captopril, enalapril, perindopril /:
Risk of a decrease in blood pressure and / or acute renal failure when treatment with an ACE inhibitor is administered to patients with a loss of sodium / particularly in patients with renal artery stenosis /.
The effect of taking Indapen SR may change or occur side effects if you are taking the following medicines:
Metformin / used for the treatment of diabetes /;
Baclofen / used to treat muscle spasms /;
Cyclosporine and Tacrolimus / used to treat autoimmune diseases or to suppress the immune system after transplantation /;
Steroids / example prednisolone, hydrocortisone or fludrocortisone / used to treat various conditions, including severe asthma and rheumatoid arthritis;
Stimulant laxatives / as senna /;
Some medicines used to treat heart failure and some abnormal heart rhythm / as digoxin, digitoxin /;
Some potassium-sparing diuretics / water tablets / as amiloride, spironolactone, triamterene;
Some water tablets, which can lead to reduced levels of potassium in the blood, such as bendroflumethiazide, furosemide, piretanide, bumetanide and xipamide;
Some antidepressants / example imipramine / neuroleptics / used for the treatment of mental disorders /;
Some drugs containing iodine / used to diagnose certain diseases /;
Tetracosactide / used for the diagnosis of certain diseases and the treatment of gastrointestinal disorders /;
Medicines containing calcium.
Adoption of Indapen SR with food and drink
Food and drink do not affect the way your medicine works. You can take it during meals or after, and on an empty stomach.

Pregnancy and lactation
Pregnancy:
This medicine is not recommended during pregnancy. Consult your doctor if you are pregnant or want to become pregnant.

Breastfeeding
The active substance passes into breast milk. Therefore, it is recommended to be used during lactation. Consult your doctor or pharmacist before taking any medication.

Driving and using machines
Indapen SR lowers blood pressure, which can cause dizziness related to low blood pressure, especially at the beginning of treatment or supplementation of other antihypertensive agents. In this case, you should not drive or operate machinery.

Important information about some of the ingredients of Indapen SR
Your medicine contains the sugar lactose. If your doctor told you that you have an intolerance to some sugars, contact him before taking this medicine.

3. HOW TO TAKE Indapen SR
Follow your doctor's instructions when taking Indapen SR. If you are unsure, consult your doctor.
The normal dose is 1 tablet per day, preferably in the morning.

Patients with impaired renal function
Patients with impaired renal function / creatinine clearance below 30 ml / min / should not be treated with Indapen SR / see p.2. "Do not take Indapen SR /.
Thiazide diuretics are fully effective only when renal function is normal or slightly impaired.

Patients with impaired hepatic function
Patients with severe hepatic impairment should be treated with Indapen SR / see section 2 "Do not take Indapen SR" /.

Elderly
Elderly patients can be treated with Indapen SR, when renal function is normal or only slightly damaged.

Children and adolescents
Indapen SR is not recommended for children and adolescents due to lack of data on safety and efficacy in them.

Method of administration
The tablets should be swallowed whole with sufficient water / eg a glass of water /. Do not crush or chew. Indapen SR can be taken with or without food.

Duration of treatment
The duration of treatment is determined by the attending physician.
If you think that the effect of Indapen SR is too strong or too weak, talk to your doctor.

If you take more than the required amount Indapen SR
In case of overdose will increase the side effects diuretic effect will increase the risk of lowering blood pressure and disorders vodnoelektrolitniya balance. If you accidentally swallowed more than the required amount Indapen SR, contact your doctor immediately. Symptoms of overdose may include nausea, vomiting, low blood pressure / leading to dizziness / cramps, dizziness, drowsiness, confusion, excessive or insufficient urination.

If you forget to take a tablet Indapen SR
If you forget to take a tablet, take it as soon as you remember a double dose to compensate for the missed dose.

If you stop taking Indapen SR
Usually the treatment of high blood pressure lasts a lifetime. You should not stop taking the medication without first discussing it with a doctor.

If you have further questions on the use of this medicine, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS
Like all medicines, Indapen SR can cause side effects, although not in all patients.

May occur following side effects:
Often / less than one in 10, but more than one in 100 /:
Allergic reactions / especially in patients prone to allergic or asthmatic reactions / koitomogat cause maculopapular skin eruptions.
Uncommon / less than one in 100, but more than one of the 1000 /:
Vomiting;
Allergic / particularly in patients prone to allergic or asthmatic reaction /, which may cause a purple spots on the skin.
Rarely / less than 1 in 1,000, but more than 1 in 10,000 /:
Dizziness;
Fatigue;
Headache;
Needles / paresthesia /;
Nausea;
Constipation / hard, dry stools /;
Dry mouth.
Very rarely / less than 1 in 10,000 /:
Reduction in blood platelets which increases risk of bleeding or bruising;
Decrease of white blood cells, leading to more frequent infections and may adopt severe / agranulocytosis /;
Reducing the levels of certain blood cells, which can cause weakness, injury, or increase the risk of infection / hemolytic anemia /; aplastic anemia / bone marrow depression /;
Inflammation of the pancreas which causes severe pain in the abdomen and back / pancreatitis /;
Uneven heartbeat;
Low blood pressure may cause dizziness;
Kidney disorders;
Liver disorders;
Increasing levels of calcium in the blood;
Serious allergic reactions / angioedema, especially in patients prone to allergic or asthmatic reactions / swelling of the face, lips or tongue and rash similar to nettle, swelling of the mucous membranes of the throat or airways, which causes shortness of breath or difficulty swallowing. In these cases, inform your doctor immediately;
Serious allergic reactions with flu-like symptoms, skin, mouth, eyes and genitals / toxic epidermal necrolysis syndrome Steven Johnson /. In these cases, inform your doctor immediately.
You may also occur following adverse reactions. Available data, however, not possible to assess how often they occur:
Indapen SR may result in low levels of sodium or potassium in the blood. Your doctor may monitor these levels via blood count / see above "Take special care with Indapen SR" /;
Indapen SR can cause reduced blood volume / hypovolemia / with dehydration and lowering of blood pressure when standing / orthostatic hypotension /;
Indapen SR may cause an increase in blood sugar levels;
If you have liver disease, intake Indapen SR may cause a condition that is called hepatic encephalopathy / injury of the brain and the nerves, which can occur as a complication of liver disease /;
If you suffer from a condition called "acute disseminated lupus erythematosus" / rare inflammatory disease / intake Indapen SR may aggravate the disease;
Taking Indapen SR can make your skin more sensitive to UV-radiation / See above "Beware of taking Indapen SR" /;
Indapen SR can cause elevated levels of uric acid in the blood and lead to gout attacks.
If any of the side effects gets serious, or if you notice any not listed is the leaflet, please tell your doctor.

5. HOW TO STORE Indapen SR
Keep out of the reach of children.
Store below 30 ° C.
Do not use after the expiry date stated on the packaging. The expiry date refers to the last day of the month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. FURTHER INFORMATION
What Indapen SR
The active ingredient is indapamide. One prolonged-release tablet contains 1.5 mg indapamide.