Hlophazolin 1 ml. 10 ampules

WHAT HLOFAZOLIN INJECTIONS?

Each ampoule of 1 ml solution for injection contains drug clonidine hydrochloride 0,15 mg.
Other ingredients: water for injection to 1 ml.
 
PHARMACEUTICAL FORM AND CONTENTS


Injection.
Colorless glass ampoules with a capacity of 1 ml, 10 blister of PVC rigid film, 1 or 5 blisters in a box along with a leaflet with instructions for use.
 
 
WHAT HLOFAZOLIN?


Hlofazolin belongs to a group of antihypertensive (blood pressure lowering) drugs. It lowers blood pressure, slows heart rate and removes resistance in peripheral blood vessels. The action starts after less than 10 minutes after the injection, reaching a maximum after about 30-60 minutes and lasts 3 to 7 hours.
 
WHAT IT IS USED HLOFAZOLIN?

Hlofazolin injection is used in hypertensive crisis (sudden increase in blood pressure).
 
WHEN NOT TO BE USED HLOFAZOLIN?
 
You should not apply Hlofazolin injection in the following cases:
• If you are allergic to the active substance;
• AV block II-III degree (impaired conduction between the atria and chambers of the heart);
  • Syndrome Sick sinus (difficulty in conducting from the sinus node to the atrium of the heart)
• Acute myocardial infarction;
 
BEFORE TREATMENT HLOFAZOLIN

Tell your doctor if you have other heart disease such as coronary artery disease, cerebrovascular disorders, kidney disease. Pregnancy and lactation
Tell your doctor if you are pregnant or plan to become pregnant. Before taking any medicine during pregnancy, be sure to consult your doctor.
If you are pregnant Hlofazolin treatment is performed only under medical supervision. Tell the doctor if you are breastfeeding as clonidine (active ingredient) passes into breast milk.
Effects on ability to drive and use machines
Readings in which the injection Hlofazolin exclude the possibility to drive and use machines.
 
What medications may interact with HLOFAZOLIN?
Please tell your doctor about ALL medications you are taking or have recently taken, whether prescription or you bought them without a prescription.
This is important because Hlofazolin can alter the activity of certain drugs, or conversely, some drugs to change its effects. Tell your doctor if you take:
• other medicines to lower blood pressure as diuretics, calcium channel blockers (eg, verapamil), ACE inhibitors (captopril); beta-blockers (propranolol) or cardiac glycosides (digoxin);
• drugs for the treatment of depression or psychosis;
• antirheumatic anti-inflammatory drugs;
• sedatives, tranquilizers;
• medicines used to treat allergies.
Do not use alcohol or alcohol-containing medicines during treatment with Hlofazolin.
 
DOSAGE AND METHOD OF ADMINISTRATION

Dose and duration of treatment is determined by your doctor.
Method of administration: Administer subcutaneously, intramuscularly or intravenously by qualified medical personnel with the ability to monitor blood pressure.
  Children: So far not proven effectiveness and safety of the product and is therefore not recommended for use in children.
 
SIDE EFFECTS

Like all medicines, Hlofazolin can have side effects. They did not necessarily occur in all patients, so you can not get any response.
During treatment with Hlofazolin possible following side effects: dry mouth, nausea, vomiting, headache, dizziness, slow heart rate, tremors of the limbs, drowsiness, itching, rashes and redness of the skin. Hlofazolin injection may induce orthostatic hypotension (low blood pressure when standing, resulting in dizziness and vertigo). In some patients after intravenous administration is not possible initial increase in blood pressure with rapid introduction followed its decline.
For adverse effects, including those not listed in this leaflet, tell your doctor.
 
STORAGE

Protected from light at a temperature below 25 ° C. Do not freeze! Keep the ampoules in the outer carton.
Keep the ampoules in a safe place where children can not see them and reach.
The drug should not be used after the expiry date stated on the packaging.
FOR SUPPLY

With a prescription.
  Method of administration:
Administered subcutaneously, intramuscularly or slowly intravenously by qualified medical personnel with the ability to monitor blood pressure. In case of intravenous administration the contents of the ampoule are diluted with 10 ml of physiological saline and injected slowly intravenously into the patient supine. The dose is determined individually depending on the blood pressure values. As soon as possible it is necessary to switch to oral therapy. Adults: treatment can begin with subcutaneous or intramuscular dose 0,15 - 0,30 mg (1 to 2 ampoules). If necessary, can be applied to 0,75 mg (5 ampoules) intravenously for 24 hours.
The hypotensive effect occurring less than 10 minutes and reaches its maximum after about 30-60 minutes and lasts 3 to 7 hours. Children: So far not proven effectiveness and safety of the product and is therefore not recommended for use in children.
Patients with renal insufficiency: As clonidine is excreted unchanged in urine primarily in patients with impaired renal function the dose should be individualized according to the therapeutic response and follow-up values of creatinine clearance. Patients with hypertension who are on hemodialysis no further administration of clonidine after each procedure, because only a small part of the administered dose is removed from the body.
Elderly (over 65) - dosage adjustment is necessary only
in patients with impaired renal function.
 
overdose
Symptoms: There are somnolence, hypotension, bradycardia, impaired AV conduction coma.
Treatment: symptomatic treatment is carried out - water-salt solutions, respiratory and cardiovascular resuscitation if necessary.