FINLEPSIN 200 mg. 50 tablets

WHAT FINLEPSIN 200 mg TABLETS AND WHAT IT IS USED?
Finlepsin Each tablet contains 200 mg of carbamazepine. Finlepsin belongs to the group of anti-epileptic drugs. Finlepsin used for treatment of:
• epilepsy: partial seizures with complex symptomatology (psychomotor seizures); partial onset seizures with elementary symptoms (simple focal seizures); generalized tonic-clonic seizures (grand mal) secondarily generalized tonic-clonic seizures, generalized tonic-clonic seizures during sleep; mixed forms of epilepsy.
• relapsing occurring pain of the face (trigeminal neuralgia)
• trigeminal neuralgia
• idiopathic glossopharyngeal neuralgia
• painful conditions in diabetic neuropathy
• non-epileptic seizures in multiple sclerosis, such as trigeminal neuralgia, tonic spasms, paroxysmal dysarthria and ataxia and paresthesia paroxysmal pain attacks.
• acute mania and podadrzhashto treatment of bipolar affective disorders prevention or reduction of relapses.
• preventing alcohol withdrawal seizures in *.
* When this indication Finlepsin should be used only in stationary conditions.
2. BEFORE YOU TAKE FINLEPSIN 200 mg tablets
You should not take Finlepsin 200 mg tablets if:
• have bone marrow damage
• have heart conduction abnormalities
• presence of hypersensitivity to carbamazepine or tricyclic antidepressants
• have a blood disorder called porphyria
• In the last 14 days you are taking medicines known as monoamine oxidase (MAO) inhibitors used to treat depression
• During concomitant treatment with voriconazole
Finlepsin should not be administered concomitantly with lithium (see. "Taking other medicines) Since Finlepsin can cause a certain type of attacks (so-called. Absences) and myoclonus, respectively, can exacerbate the appearance of existing, it should not to be used in patients who have this type of fit.
Take special care with Finlepsin 200 mg tablets
Finlepsin should not be prescribed to patients only in strict observance of the benefit / risk and appropriate precautions in the following cases:
• hematological diseases (blood diseases)
• grave breaches of the function of the heart, liver and kidneys,
• disturbances in sodium metabolism.
Note: For children under 6 years carbamazepine should be administered only after a rigorous assessment of the benefit / risk ratio.
A small number of people being treated with antiepileptics such as carbamazepine have had thoughts of harming or killing themselves. If these occur, immediately contact your doctor.
In patients with glaucoma should be periodically monitored intraocular pressure. Finlepsin be taken with lithium only in exceptional cases, for the prevention of manic-depressive states or their insufficient response to lithium. In this case, to avoid adverse interactions (see "Taking other medicines"), care must be taken not to exceed a certain plasma concentration of carbamazepine (8 (μg / ml), and the plasma level of lithium to keep within lower therapeutic area (0,3-0,8 mval / l). The intake of neuroleptics should be discontinued no later than eight weeks before starting treatment with carbamazepine or not to hold a joint treatment. During treatment with carbamazepine patients should avoid excessive exposure to sunlight because of the risk of photosensitivity (sensitivity to light HD skin).
The use of carbamazepine were reported serious skin rashes (Stevens-Johnson, toxic epidermal necrolysis). Often the rash may include ulcers in the mouth, throat, nose, genitals and conjunctivitis (red and swollen eyelids). These serious skin rashes are often preceded by symptoms such as fever, headache, body aches (flu-like symptoms). The rash may progress to generalized blistering and peeling of the skin. The highest risk for serious skin reactions during the first months of treatment.
These serious skin reactions may be more common in people from certain Asian countries. The risk of these reactions in patients from China or Thailand can be provided by testing blood samples from these patients. Your doctor should advise you if you need to do blood tests.
If you get a rash or these skin symptoms, stop taking carbamazepine and immediately consult your doctor.
Rarely serious adverse skin reactions during treatment with Finlepsin 200 mg tablets. For patients of Asian origin from China and Thailand, the risk of their appearance can provide a blood sample. If you are Chinese or Thai origin, please consult your doctor before starting treatment with Finlepsin 200 mg tablets.
Taking other medicines
• Before starting treatment with carbamazepine, you need at least two weeks before it is eventually completed treatment with MAO inhibitors.
• In concomitant administration of other anti-epileptic drugs (eg. Phenytoin, phenobarbital, primidone) with carbamazepine may mutually weaken the antiepileptic effect, but in rare cases the effect can be enhanced. It is therefore necessary to control the plasma level of carbamazepine and of other AEDs. Combinations with valproic acid may lead to coma exceptionally and conditions of disorientation.
• In co-administration of carbamazepine and oral anticoagulants and drugs (anticoagulants) can reduce their effect.
So when starting or stopping treatment with carbamazepine, the dose of anticoagulants should be brought into line with clinical requirements.
• Finlepsin may weaken the effect of contraceptive drugs. Therefore, it may appear sudden intermediate bleeding. In such cases it is recommended to apply other birth control pills.
• Patients who are treated with neuroleptics should be careful, as carbamazepine reduces plasma levels of these drugs and may cause worsening of the disease picture. It may need adapting the dose of the neuroleptic. Coadministration of lithium and carbamazepine may intensify the neurotoxic actions of both drugs. So if you need to be adopted at the same time, careful clinical monitoring of their blood level.
Care must be taken for the following signs of neurotoxic symptoms: disorientation, abnormal movements and gait (ataxia), tremor of the eyes (horizontal nystagmus), enhanced muscle reflexes, muscle twitching (faspikulatsii).
• Plasma concentrations of carbamazepine may be increased by: macrolide antibiotics (erythromycin);
• isoniazid (for treating tuberculosis);
• Calcium antagonists (eg. Verapamil, diltiazem), used to treat high blood pressure and heart problems;
• dextropropoxyphene and other painkillers;
• viloksatsin and possibly cimetidine. In rare cases may follow amplify the action of propoxyphene.
• The therapeutic effect of tetracyclines may weaken.
Other drugs that should inform your doctor are: itraconazole (antifungal), praziquantel (used for the treatment of parasitosis), drugs against certain tumors (imatinib), for the treatment of HIV infection, drugs used in asthma (theophylline) corticosteroids, immunosuppressive drugs (cyclosporine) and levothyroxine.
It is recommended to monitor plasma levels of carbamazepine and other drugs when possible combination therapy to reduce respectively eliminate the manifestations of adverse reactions (eg. Dizziness, headache, abnormal movements, shaking of the eyes, visual disturbances).
Please tell your doctor if you have recently taken and others including medicines obtained without a prescription.
Taking Finlepsin 200 mg tablets with food and drink:
Like other substances that affect the nervous system, karbamazelin can reduce patient tolerance to alcohol. Therefore during treatment Finlepsin avoid alcohol as it unpredictable can change or enhance its action.
Pregnancy and lactation
Ask your doctor before taking any medicine.
Carbamazepine should not be administered during pregnancy, but in patients with relapses, the necessary antiepileptic treatment can not be applied. The risk of congenital malformations is increased in pregnant women suffering from epilepsy, respectively. treatment with anti-epileptics, possibly also with carbamazepine. That is why women who want to become mothers, it is imperative to consult a doctor. Use of carbamazepine should be preceded necessarily strict assessment of the benefit / risk ratio by your doctor. In existing pregnancy or in early pregnancy, especially between the 20th and 40th day, carbamazepine should be administered in the lowest possible doses. The daily dose should be distributed more smaller doses throughout the day.
Combination with other anti-epileptics and other drugs during pregnancy should be avoided, as the risk of malformation in combination therapy increases. To avoid the risk of bleeding in newborns taken prophylactic vitamin Ki mother in the final weeks of pregnancy, respectively after birth is recommended for newborns.
Carbamazepine passes into breast milk in very limited quantities, so in therapeutic doses does not pose a danger to the child. If it is found abnormal weight gain or increased need for sleep (sedation) in the infant, breast-feeding should be discontinued.
Driving and using machines
Although administered as prescribed, carbamazepine can so much change reactivity that impair your ability to actively participate in traffic or working machines. This applies to a greater extent in the reaction with alcohol.
Other warnings:
• Alcohol can affect you worse than usual. Check with your doctor.
• Grapefruit juice can increase the likelihood of side effects.
• Your doctor may decide that it is necessary more often conduct blood tests before starting treatment and during treatment.
3. HOW TO TAKE FINLEPSIN 200 mg tablets?
Treatment with carbamazepine gradually with a low initial dose, depending on the type and severity of the disease judging is an individual, then the dose was increased slowly to a maintenance therapeutic dose. The optimal dose, especially when combination therapy is determined after study of plasma levels. When switching to treatment with carbamazepine, the dose of anti-epileptic whose intake is terminated should be reduced gradually. In the treatment of epilepsy it is advisable to prescribe carbamazepine alone (monotherapy). Treatment should be supervised by a physician specialist.
Typically prescribed 400-1 200 mg carbamazepine daily, divided into 3-4 doses. In practice it was found that the therapeutic plasma level of carbamazepine is between 4-12 (Ag / ml. In some cases the required dose can deviate from that starting and maintenance dose (eg. Because of accelerating metabolism through enzyme induction or due to drug interactions with optionally combined treatment.
Overrun of the total dose of 1 mg Carbamazepine 200 is not recommended. In some cases, the division of the daily dose of 4-5 divided doses is particularly effective. In severe cardiovascular disease, in hepatic and renal diseases, as well as in older patients are recommended lower doses. In the absence of particular prescription apply the following recommendations for dosing.
Anticonvulsant treatment:
Typically adult starting dose of 200-300 mg per day was increased slowly until a maintenance dose of 600 to 1200 mg daily. It is distributed in 3-4 divided doses. Maintenance dose for children reaches an average of 10-20 mg / kg body weight per day.
It is recommended that the following dosage regimen:
age daily starting dose daily maintenance dose
adults one time 200 mg 3 times x 200-400 mg
* children up to 1 year see the instructions 1-2 times x 100 mg
1-5 years see the instructions 1 -2 times x 200 mg
5-10 years times 2 x 100 mg 2-3 times x 200 mg
10-15 years 2 times x 100 mg 3-5 times x 200 mg
Notes: Children under 4 years of treatment starts with a daily dose of 20-60 mg daily (= 5 mg / kg). While the optimal dose is reached, this dose may be increased every two days with 20-60 mg daily. For children over 4 years, the starting dose can reach 100 mg daily. This daily dose may be increased every ne days to 100 mg daily up to the optimal dose, it must not be exceeded under the above indicated dose to 10-20 mg / kg.
Prevent attacks during inpatient treatment of alcoholism average daily dose is 3 times 200 mg per day. In severe cases, the starting dose in the first days can be increased to 3 times 400 mg per day. Not recommended combining carbamazepine with sedative-hypnotic drugs for delirium tremens. Must perform regular izsladvaniya plasma levels. Treatment with carbamazepine should be discontinued with gradually decreasing doses for 7-10 days.
Relapsing occurring pain of the face (trigeminal neuralgia), breakthrough pain of unknown cause in the pharynx (idiopathic glossopharyngeal neuralgia) The starting dose is 200-300 mg daily and increased to stop the pain, usually 400-800 mg daily, divided more individual doses. Subsequently, in some patients, the dosage to be reduced to a lower, but still eliminates the pain attacks maintenance dose of 400-600 mg daily, in divided doses. In older patients and is sensitive enough initial dose of 200 mg daily.
Pain conditions due to nerve damage in diabetes (pain in diabetic neuropathy)
The average daily dose of 200 mg three times daily, and exceptionally 400 mg three times daily.
Non-epileptic seizures in multiple sclerosis: The average daily dose of 200 mg, 2-4 times daily.
Acute mania and prophylaxis of bipolar affective disorders:
Dosage range: about 400-1600 mg daily, the usual dose is 400-600 mg daily in 2-3 divided doses. In the treatment of acute mania, the dosage should be increased faster while preventing bipolar recommended smaller increments to ensure optimum tolerance.
Carbamazepine should be used in acute schizophrenia nevropeptichno treatment with carbamazepine may apply and manic-depressive illness in combination with lithium, with careful observance of the precautions (see. "Taking other medicines)
Method and duration of administration
Tablets should be taken during or after a meal with liquid.
The duration of use is based on the type of disease and the individual response and is determined by your doctor. In no case shall willfully stop treatment with this medicine.
Overdose and other errors in use
If you take more dose 200 mg tablets Fiilepsin In case of overdose require immediate medical attention. Overdose with carbamazepine may enhance the occurrence of side effects such as. shaking (tremor), brain seizures (tonic-clonic convulsions), agitation manifested as a disorder in respiratory or cardiovascular system that occurs primarily with reduced blood pressure (possibly high blood pressure), increased heart rate (tachycardia), conduction disorders and excitability of heart muscle (AV-block, ECG changes), impaired consciousness to respiratory arrest and heart. In some cases observed leukopenia, neutropenia, glycosuria or acetonuria that occur with altered laboratory parameters.
A specific antidote for acute intoxication with carbamazepine is not known. Treatment of overdose is manifested depending on the symptoms and must be performed in a hospital setting.
If you forget to take or have taken too little Finlepsin 200 mg tablets
If you forget to take a tablet, take it as soon as you remember unless it is almost time for your next dose. DO NOT take a double dose to make up the missed dose. Take your next dose at the usual time.
If you stop taking Finlepsin 200 mg tablets
You should continue taking these tablets so long as you
recommended by your doctor. Willfully change the dose or treatment discontinuation
may be hazardous to your health. This can lead to a worsening of symptoms. Do not stop taking your medicine unless you have consulted with your doctor.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Finlepsin can cause side effects, although not everybody gets them.