EUTIROKS. 125 mcg. 90 tablets

EUTIROKS WHAT IS AND WHAT IT IS USED
Levothyroxine Eutiroks active substance is a synthetic thyroid hormone for the treatment of disorders and thyroid dysfunction . It has the same effect as the naturally occurring thyroid hormones.

Eutiroks be used:
for treatment of benign goiter in patients with normal thyroid function ;
for the prevention of recurrence after surgery on neck ;
Replacement of the natural thyroid hormone in a reduced production of hormones by your thyroid ;
for inhibiting tumor growth in a patient with cancer of the thyroid gland .
Eutiroks 25 micrograms , 50 micrograms , 75 micrograms and 100 micrograms were used to balance the levels of thyroid hormones , where the overproduction of hormones can be treated with anti-thyroid drugs.
Eutiroks 100 micrograms can be used to study the function of the thyroid gland you .

2 . BEFORE YOU TAKE EUTIROKS
Eutiroks not take if you have:
are allergic (hypersensitive ) to the active substance or to any of the ingredients of Eutiroks (see section 6 . )
untreated dysfunction of the adrenal gland , pituitary or excessive overproduction of thyroid hormones ( thyrotoxicosis)
acute heart disease ( myocardial infarction , or inflammation of the heart).
If you are pregnant , do not take Eutiroks with antithyroid drugs ( see section "Pregnancy and lactation " below ) .

Take special care with Eutiroks
if you have any of the following heart diseases:
insufficient blood flow in the blood vessels of the heart ( angina pectoris ) ;
heart failure ;
rapid or irregular heartbeat ;
high blood pressure ;
fatty deposits in the arteries ( atherosclerosis ) .
They must be medically controlled before you start taking Eutiroks or before suppressive thyroid study . While on Eutiroks levels of thyroid hormones you need to be tested often. If you are unsure whether you have any of these disorders or if you are receiving treatment , contact your doctor.
Your doctor will do tests if you have a dysfunction of the adrenal or pituitary or thyroid dysfunction with uncontrolled overproduction of thyroid hormones ( thyroid autonomy ), since they must be medically controlled before you start taking Eutiroks or before suppressive examination of the thyroid.
Ask your doctor :
if you are menopausal or post-menopausal , you may need your doctor to regularly examine your thyroid function because of the risk of osteoporosis ;
If you switch from one containing levothyroxine drug to another . The effect may be slightly different and you may need more frequent monitoring and dose adjustment .
Taking other medicines
Tell your doctor if you are taking any of these medicines as Eutiroks can influence their effects :
Antidiabetic drugs ( drugs that lower blood sugar ): Eutiroks can reduce the effect of your diabetes medicine, so you may need more research on the blood sugar levels , especially at the beginning of treatment Eutiroks . While taking Eutiroks may need to adjust the dose of your diabetes medicine ;
Coumarin derivatives (medicines used to prevent blood clotting ): Eutiroks may increase the effects of these drugs may increase the risk of bleeding , particularly in elderly patients . You may need regular monitoring of coagulation parameters at baseline and during treatment with Eutiroks . While taking Eutiroks may need to adjust the dose of coumarin .
Make sure you stick to the recommended intervals intake if you should take the following medicines:
Drugs that bind to bile acids and lowering high cholesterol (such as cholestyramine or colestipol) : Make sure that you take Eutiroks 4-5 hours before these medicines as they can block the absorption of Eutiroks the gut ;
Antacids ( to relieve heartburn ) , sucralfate ( for ulcers of the stomach or intestine ) , other medications containing aluminum , iron containing drugs , calcium carbonate : Make sure that you take Eutiroks least 2 hours before these drugs as otherwise If they can reduce the effect of Eutiroks .
Tell your doctor if you are taking any of the following medicines as they may reduce the effect of Eutiroks :
propylthiouracil ( antithyroid drug) ;
glucocorticoids ( anti-allergic and anti-inflammatory drugs ) ;
beta blockers (drugs that lower blood pressure , and used for the treatment of heart disease ) ;
Sertraline ( antidepressant drug ) ;
chloroquine or progvanil ( medicines for the prevention or treatment of malaria ) ;
drugs activating certain liver enzymes , such as barbiturates ( sedatives , hypnotics) or carbamazepine ( an antiepileptic drug used for the modification of certain types of pain , and for the control of mood ;
estrogen containing medications , used as hormone replacement therapy during or after the menopause or for contraception ;
Sevelamer ( medicine phosphate binder for the treatment of patients with chronic renal failure) ;
tyrosine kinase inhibitors ( anti-tumor and anti-inflammatory drugs ) .
Tell your doctor if you are taking any of the following medicines as they may enhance the effect of Eutiroks :
salicylates ( drugs used for pain relief and for lowering the temperature ) ;
dicoumarol (a medicine to prevent blood clotting ) ;
furosemide at high doses of 250 mg ( diuretic drug) ;
clofibrate (a medicine for lowering blood lipids ) .
Tell your doctor if you are taking any of the following medicines as they may interfere with the effect of Eutiroks :
ritonavir , indinavir , lopinavir ( protease inhibitors , drugs for the treatment of AIDS ) ;
phenytoin ( an antiepileptic drug) .
You may need regular testing the levels of thyroid hormones you . It is possible dose adjustment Eutiroks .

Tell your doctor if you are taking amiodarone (a medicine used to treat irregular heart beat), as this medicine may have an effect on the function and activity of your thyroid gland.
If you need a diagnostic test or scan with iodinated X-ray contrast material , tell your doctor that you are taking Eutiroks because you may be an injection , which affect the function of your thyroid gland.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Thyroid hormones are not suitable for reduction in weight. If the level of thyroid hormones in your normal range on thyroid hormones will reduce your weight. If you increase the dosage without special recommendation from your doctor may arise serious or even life-threatening side effects .

Taking Eutiroks with food and drink
Tell your doctor if you are using soy products , especially in case the amount you use. Soy products may reduce the absorption of Eutiroks the gut and therefore may require dose adjustment of Eutiroks .

Pregnancy and lactation
If you are pregnant , keep taking Eutiroks . Talk to your doctor as you may need your dose is changed.
If you take Eutiroks with antithyroid drugs to treat the overproduction of thyroid hormones when pregnant , your doctor will recommend you to stop treatment with Eutiroks .
If you are breastfeeding , continue taking Eutiroks as recommended by your doctor. The amount of drug that is excreted in human milk , is so small that it will not affect the child.

Driving and using machines
No studies on the ability to drive and use machines.
Not expected to have any Eutiroks affect the ability to drive and use machines as levothyroxine the same as the naturally occurring thyroid hormone .

Important information about some of the ingredients of Eutiroks
Eutiroks contains lactose monohydrate. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before using this medicine.

3 . HOW TO TAKE EUTIROKS
Always take Eutiroks exactly as your doctor tells you . If you are not sure, ask your doctor.
Based on surveys and laboratory tests, your doctor will determine your individual dose. As a rule, starting with a low dose, which is increased every 2-4 weeks , until reaching the complete individual dose . During the first weeks of treatment will be appointed laboratory research to clarify the dose.
If your baby has congenital hypothyroidism , your doctor may advise you to start his treatment with higher dose because it is important for the application of immediate replacement therapy . The table below shows the usual dosage range .
May be sufficient for lower doses:
if you are an elderly patient ;
if you have heart problems;
If you lower your thyroid gland is severe or prolonged ;
if you have weight loss or big enough.
Use of Eutiroks Recommended Daily Eutiroks
for the treatment of benign goiter patients with normal thyroid function 75-200 micrograms
for the prevention of recurrence after surgery goiter 75-200 micrograms
Replacement of the natural thyroid hormone in a reduced production of thyroid
starting dose
maintenance dose
adults
25-50 micrograms
100-200 micrograms
children
12.5 to 50 micrograms
100-150 micrograms per m2 body surface
suppression of tumor growth in patients with cancer of the thyroid gland 150-300 micrograms
Balancing of thyroid hormones , where the overproduction of hormones can be treated with anti-thyroid drugs 50-100 micrograms
for measurement of thyroid function 100 micrograms :
200 micrograms ( Table 2 . Daily) two weeks prior to the survey
application
Eutiroks is intended for oral administration. The overall daily dose will be taken in the morning under fasting conditions ( at least half an hour before breakfast ), preferably with liquid , for example with half a glass of water. Infants can take the full daily dose Eutiroks least half an hour before the first meal of the day . Immediately before use, the crushed tablet , mix it with some water and give it to the baby , such as dilute the mixture with a little liquid. Always making mixtures immediately before use.

Duration of treatment
The duration of treatment may vary , depending on the condition you use Eutiroks . Therefore, your doctor will discuss with you how long you should take it . Most patients received Eutiroks for life.

If you take more dose Eutiroks
If you take the dose more than prescribed , you may experience symptoms such as rapid heart rate , anxiety , excitement or involuntary movements. In patients with disorders of the nervous system, eg . epilepsy may occur isolated cases of seizures.
If this happens , call your doctor.

If you forget to take Eutiroks
Do not take a double dose to make up for the missed tablet and take your normal dose on the next day.
If you have any further questions on the use of Eutiroks , ask your doctor or pharmacist.

4 . POSSIBLE SIDE EFFECTS
Like all medicines, Eutiroks can cause side effects, although not everybody gets them .
If you take Eutiroks at a dose higher than prescribed , or if you can not tolerate the prescribed dose (ie the dose increases rapidly ) , you may get one or more of the following side effects:
Irregular or rapid heartbeat , chest pain , headache , muscle weakness or cramps , flushing (heating and flushing ), fever , vomiting , abnormal menstruation , pseudotumor cerebri (increased pressure in the head with swollen eyes) , trembling, restlessness, sleep disturbances , sweating, weight loss, diarrhea.
If any of these side effects, contact your doctor. Your doctor may decide to stop treatment for several days or to reduce the daily dose until no side effects .
Possible allergic reaction to any component of Eutiroks (see section 6 . " What does Eutiroks " ) . Allergic reactions may occur with swelling of the face or throat ( angioedema ) . If this happens , contact your doctor immediately .

If any of the side effects gets serious, or you notice other effects not listed in this leaflet , please tell your doctor or pharmacist.

5 . HOW TO STORE EUTIROKS
Keep out of reach of children.
Eutiroks not use after the expiry date stated on the blister and carton after " EXP" . The expiry date refers to the last day of that month.
Do not store above 25 ° C. Keep the blister in the outer carton to protect from light.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required . These measures will help to protect the environment.

6 . ADDITIONAL INFORMATION
What does Eutiroks
The active substance is levothyroxine . Each tablet contains 25 micrograms , 50 micrograms , 75 micrograms , 100 micrograms , 125 micrograms of levothyroxine sodium.
Other ingredients are: corn starch , croscarmellose sodium, gelatin , lactose monohydrate and magnesium stearate.