Candesartan НСТ 16 mg. / 12.5 mg. 30 tablets

What is Candesartan HCT Actavis is and what it is used
The name of your medicine is HCT Candesartan Actavis 8 mg / 12,5 mg (16 mg / 12,5 mg) tablets. To be used for the treatment of high blood pressure (hypertension) in adult patients. It contains two active ingredients: candesartan cilexetil and hydrochlorothiazide. They work together to lower your blood pressure.
Candesartan cilexetil belongs to a group of medicines called angiotensin II receptor antagonists. It causes your blood vessels to relax and widen. This helps to lower your blood pressure.
Hydrochlorothiazide belongs to a group of medicines called diuretics (water tablets). It helps your body to remove water and salts, for example. sodium with urine. This helps to lower your blood pressure.
Your doctor may prescribe Candesartan HCT Actavis if your blood pressure is not controlled properly in self-administration of candesartan cilexetil and hydrochlorothiazide.

2. What you should know before using Candesartan HCT Actavis
Do not use Candesartan HCT Actavis:
if you are allergic (hypersensitive) to candesartan cilexetil or hydrochlorothiazide or any of the other ingredients of Candesartan HCT Actavis (see section 6);
if you are allergic to sulfonamides. If you are not sure if any of these apply to you, ask your doctor;
if you are more than 3 months pregnant (it is better also to avoid Candesartan HCT Actavis in early pregnancy - see pregnancy section);
if you have severe kidney problems;
if you have severe liver disease or obstruction of the gallbladder (problems with the drainage of bile from the gall bladder);
if you have a constant low levels of potassium in her blood;
if you have a constant low levels of calcium in their blood;
if you have ever had gout.
If you are not sure that any of these apply to you, ask your doctor or pharmacist before taking Candesartan HCT Actavis.

Warnings and Precautions
Before or while taking Candesartan Actavis HCT, tell your doctor if:
have diabetes;
you have heart problems, liver or kidney;
You have recently had a kidney transplant;
vomiting, have recently had severe vomiting or diarrhea;
You have a disease of the adrenal gland called syndrome Conn (also called primary aldosteronism);
You have ever had a disease called systemic lupus erythematosus (SLE);
you have low blood pressure;
You have ever had a stroke;
you have ever had allergy or asthma.
You should tell your doctor if you think you are (or might become) pregnant. The use of Candesartan HCT Actavis is not recommended in early pregnancy, and should not take it if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section) .
If you have any of these conditions, your doctor may want to visit more often and you appoint some research.
If you have an operation, tell your doctor or dentist that you take Candesartan HCT Actavis. This is necessary because when Candesartan HCT Actavis combined with certain anesthetics, it may cause a reduction in blood pressure.
Candesartan HCT Actavis can cause increased skin sensitivity to sun.

Use in children
There is no experience with the use of Candesartan HCT Actavis in children (under 18 years). Therefore, Candesartan HCT Actavis should not be given to children.

Other medicines and Candesartan HCT Actavis
Tell your doctor or pharmacist if you are taking, you have recently taken or might take any other medicines. Candesartan HCT Actavis can affect the way some medicines work and some medicines can have an effect on
Candesartan HCT Actavis. If you take certain medicines, you may need your doctor to appoint blood tests from time to time.

In particular, tell your doctor if you are taking the following medicines:
Other medicines that lower blood pressure, including beta-blockers, diazoxide and Angiotensin Converting Enzyme (ACE), for example. enalapril, captopril, lisinopril or ramipril;
Non-steroidal anti-inflammatory drugs (NSAIDs), for example. ibuprofen, naproxen, diclofenac, celecoxib or etoricoxib (medicines to relieve pain and inflammation);
Acetylsalicylic acid (if taking more than 3 g each day) (medicine to relieve pain and inflammation);
Potassium supplements or salt substitutes containing potassium (medicines that increase the amount of potassium in your blood);
Supplements containing calcium or vitamin D;
Drugs to lower cholesterol, for example. colestipol or cholestyramine;
Medicines for diabetes (tablets or insulin);
Medicines to control heart rate (antiarrhythmics), for example. digoxin and beta blockers;
Drugs that can influence the levels of potassium in the blood, for example. some antipsychotic drugs;
Heparin (a medicine for thinning the blood);
Water tablets (diuretics);
laxatives;
Penicillin (antibiotic);
Amphotericin (for the treatment of fungal infections);
Lithium (a medicine for mental health problems);
Steroids, e. prednisolone;
Pituitary hormone (ACTH);
Medicines to treat cancer;
Amantadine (for the treatment of Parkinson's disease or for serious infections caused by viruses);
Barbiturates (a type of sedative drugs that are also used for the treatment of epilepsy);
Carbenoxolone (to treat disease of the esophagus or mouth ulcers);
Anticholinergic agents, eg. atropine and biperiden;
Cyclosporine - a medicine used in organ transplants to prevent organ rejection;
Other drugs that may lead to increased antihypertensive effect, for example. baclofen (a medicine for the relief of spastic states), amifostine (used to treat cancer) and some antipsychotic drugs.
Candesartan HCT Actavis with food and drink
You can take Candesartan HCT Actavis with or without food.
When you prescribe Candesartan HCT Actavis, talk to your doctor before drinking alcohol. Alcohol may make you feel weak or dizzy.
Pregnancy and lactation
If you are pregnant or breast-feeding, you think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine.

pregnancy
You should tell your doctor if you think you are (or might become) pregnant. Usually, your doctor will advise you to stop Candesartan HCT Actavis before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Candesartan HCT Actavis. The use of Candesartan Actavis HCT is not recommended in early pregnancy, and should not take it if you are more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.

breastfeeding
Tell your doctor if you are breastfeeding or about to start breast-feeding. The use of Candesartan HCT Actavis during breast-feeding is not recommended and your doctor may choose another treatment for you if you want to breastfeed.

Driving and using machines
Some people may feel tired or dizzy when taking Candesartan HCT Actavis. If this happens to you, do not drive or operate any tools or machinery.

Candesartan HCT Actavis contains lactose
Candesartan HCT Actavis contains lactose which is a type of sugar. If your doctor has told you that you have an intolerance to some sugars, contact him / her before taking this medicine.

3. HOW TO TAKE Candesartan HCT Actavis
Always take Candesartan HCT Actavis exactly as you have been told by your doctor. If you're not sure, ask your doctor or pharmacist.

It is important to take Candesartan HCT Actavis every day.
The usual dose HCT Candesartan Actavis is one tablet once daily.
Swallow the tablet with water.
Try to take the tablet at the same time each day. This will help you remember that you have to take it.
If you take more than the amount of Candesartan HCT Actavis
If you take more than your prescribed by the doctor dose HCT Candesartan Actavis, consult a doctor immediately or pharmacist.

If you forget to take Candesartan HCT Actavis
Do not take a double dose to make up for a missed tablet. Just take your next dose as usual.

If you stop taking Candesartan HCT Actavis
If you stop taking Candesartan HCT Actavis, your blood pressure may increase again. Therefore, do not stop taking Candesartan HCT Actavis without first talking to your doctor.
If you have further questions about the use of this product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. It is important to know what may have these side effects. Some of the side effects of Candesartan HCT Actavis are caused by candesartan cilexetil and some - by hydrochlorothiazide.

Stop taking Candesartan HCT Actavis and seek immediate medical attention if you experience any of the following allergic reactions:
difficulty in breathing with or without swelling of the face, lips, tongue and / or throat;
swelling of the face, lips, tongue and / or throat that may cause difficulty in swallowing;
intense itching of the skin (with raised lumps).
Candesartan HCT Actavis may cause a decrease in the number of white blood cells. Your resistance to infection may be decreased and may get fatigue, infection or fever. If this happens, contact your doctor. Your doctor may occasionally do blood tests to check whether Candesartan HCT Actavis has had any effect on your blood (agranulocytosis).

Other possible side effects include:
Common (affects 1 to 10 of 100 patients):
Changes in blood test results:
A reduced amount of sodium in the blood. If it is severe, you may feel weakness, lack of energy, or muscle spasms;
Increased or reduced amount of potassium in the blood, especially if you already have kidney problems or heart failure. If it is severe, you may experience fatigue, weakness, irregular heartbeat or "pins and needles";
Increased amount of cholesterol, sugar or uric acid in the blood;
Sugar in urine;
Feelings of dizziness / vertigo or weakness;
Headache;
A respiratory tract infection.
Uncommon (affects less than 1 in 100 patients):
Low blood pressure. This can make you feel weak or dizzy;
Loss of appetite, diarrhea, constipation, gastric irritation;
Skin rash, convex rash (urticaria), rash caused by sensitivity to light.
Rare (affects less than 1 in 1000 patients):
Jaundice (yellowing of the skin or whites of the eyes). If this happens to you, contact your doctor immediately;
Effects on the kidneys, especially if you have kidney problems or heart failure;
Difficulty sleeping, depression, anxiety;
Numbness or tingling in the hands or feet;
Blurred vision for a short time;
Abnormal heart rhythm;
Breathing difficulties (including lung inflammation and fluid accumulation in the lungs);
High temperature (fever);
Inflammation of the pancreas. This causes moderate to severe pain in the stomach;
Muscle spasms;
Damage to the blood vessels leading to the appearance of red or purple dots on the skin;
Reduction of red or white blood cells or platelets. You may experience fatigue, infection, fever or easy bruising;
Severe rash that develops quickly, with blistering or peeling of the skin and possibly blistering in the mouth;
Worsening reactions similar to lupus erythematosus, or appearance of unusual skin reactions.
Very rare (affects less than 1 in 10,000 patients):
Swelling of the face, lips, tongue and / or throat;
itching;
Back pain, pain in joints and muscles;
Changes in the liver, including liver inflammation (hepatitis). You may experience fatigue, yellowing of the skin and whites of the eyes and flu-like symptoms;
cough;
Nausea.
If you get any side effects, contact your doctor or pharmacist. This includes any possible effects not listed in this leaflet.

5. How to store Candesartan HCT Actavis
Keep out of reach of children.
Do not use this medicine after the expiry date stated on the carton after "EXP". The expiry date refers to the last day of that month.
This medicine does not require any special storage conditions.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer use. These measures will help to protect the environment.

6. Contents of the pack and other information
What Candesartan HCT Actavis
The active substances are candesartan cilexetil and hydrochlorothiazide. Each tablet contains 8 mg (16 mg) candesartan cilexetil and hydrochlorothiazide 12,5 mg.
Excipients are: lactose monohydrate, cornstarch, hydroxypropyl cellulose, croscarmellose sodium, magnesium stearate and triethyl citrate.